Digital screening plus blood biomarkers to detect early Alzheimer's changes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational study uses a stepwise screening strategy beginning with rapid digital pre-screening that combines the SCD-9 questionnaire, a brief digital cognitive assessment, and a predictive risk model to identify people at higher dementia risk. Individuals flagged by the digital screen proceed to blood-based biomarker testing to confirm Alzheimer’s pathology, with multiple novel blood markers compared head-to-head for diagnostic utility. The study recruits community-dwelling adults aged 50 and older without prior diagnoses of mild cognitive impairment or dementia across several medical centers in China. Results aim to identify which combinations of digital measures and blood biomarkers work best for early, scalable detection in real-world community settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. adults aged 50 and above;
2. living in community for at least one year and having established medical records;
3. denying a history of cognitive disorders (mild cognitive impairment, dementia, Alzheimer's disease, etc.) and the use of anti-dementia drugs (cholinesterase inhibitors or memantine, etc.);
4. agreeing to participate in the study;
5. individual or their relatives can communicate normally in Chinese.
6. high-risk groups for dementia（including:1. Complaints of cognitive decline and/or statements by the informant;2. History of AD in first-degree relatives;3. Known ApoE e4 carrier.）

Exclusion Criteria:

1. Self-reporting or confirmation through inquiry indicates the presence of severe mental disorders, such as bipolar disorder or schizophrenia, etc.
2. Having a disease that makes it impossible to complete the cognitive assessment.

Where it's running

• Xuanwu Hospital, Capital Medical University
  Beijing, China Recruiting
• Hainan Medical University
  Hainan, China Recruiting
• General Hospital of Ningxia Medical University
  Ningxiang, China Recruiting
• The First Hospital of China Medical Unversity
  Shenyang, China Recruiting
• Shenzhen Center For Chronic Disease Control
  Shenzhen, China Recruiting
• Yichun People'S Hospital
  Yichun, China Recruiting

Study contacts

• Principal investigator: Yi Tang, M.D., Ph.D — Xuanwu Hospital, Beijing
• Study coordinator: Yi Tang, M.D., Ph.D
• Email: tangyixw@vip.163.com
• Phone: 00861083199456

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.