Digital health tool to help more people start TB preventive therapy
Official title: Digital Health Intervention in Improving Preventive Treatment Initiation and Completion Among Close Contacts of Tuberculosis Patients in South Ethiopia
Run by Arba Minch University · NCT07313995 · Data updated 2026-11-12
A digital health approach is being tested to see if it helps household and close contacts of people with drug-sensitive pulmonary TB start TB preventive therapy better.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 304 (estimated) |
| Sponsor | Arba Minch University Academic / other |
| Locations | 14 sites (Arba Minch, South Ethiopia and 13 other locations) |
| Status | Recruiting |
| Started | May 22, 2026 |
| Main results expected | September 22, 2026 |
| Study ends | January 22, 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07313995 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are household or close contacts of someone with drug-sensitive pulmonary TB, residing in the specified catchment area and willing to stay at least four months.
✕Probably not a fit
Individuals with active TB symptoms, drug-resistant TB exposure, or contraindications to TPT may not benefit and are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study tests a digital health intervention aimed at increasing initiation and completion of TB preventive therapy among household and close contacts of patients with drug-sensitive pulmonary TB. Participants live in the catchment area of selected facilities in Arba Minch, Ethiopia, and stay at least four months. The study examines whether digital education and support can improve adherence and uptake of TPT compared with standard care. Key recruitment includes adults and children who are close contacts and do not have active TB or drug resistance. Outcomes will focus on TPT initiation and completion rates, with safety screened through exclusions for TPT contraindications and active TB symptoms.
Why it matters
Potential benefit: If successful, participants and their households may start and complete TB preventive therapy more effectively, reducing TB transmission risk.
How similar studies have gone: Digital health approaches have shown promise in improving treatment uptake and adherence in TB care settings, though specific results for TPT initiation are variable by context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All household and close contacts of drug-sensitive pulmonary TB patients * Living in the catchment area of the selected health facility * Willing to stay for at least 4 months in the catchment area Exclusion Criteria: * Individuals with a known allergy to TPT drugs or those contraindicated for TPT drugs * Close contacts screened as symptomatic for TB * Close contacts with drug-resistant TB * Temporary residents staying for less than 4 months
Where it's running
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Chencha Generl Hospital
Chencha, South Ethiopia, Ethiopia Recruiting -
Zadha Health center
Chencha, South Ethiopia, Ethiopia Recruiting -
Bulki Health center
Felege Neway, South Ethiopia, Ethiopia Recruiting -
Dombe Health center
Felege Neway, South Ethiopia, Ethiopia Recruiting -
Galma Health center
Felege Neway, South Ethiopia, Ethiopia Recruiting -
Lotte Health center
Felege Neway, South Ethiopia, Ethiopia Recruiting
Show 8 more locations
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Shefite Health center
Felege Neway, South Ethiopia, Ethiopia Recruiting -
Sawla General Hospital and Sawla Health Center
Felege Neway, South Ethiopia, Ethiopia Recruiting -
Arba Minch General Hospital and Dilfana Primary Hospital
Arba Minch, South Ethiopia, Ethiopia Completed -
Chano Health center
Arba Minch, South Ethiopia, Ethiopia Completed -
Gerese Primary Hospital
Arba Minch, South Ethiopia, Ethiopia Completed -
Shelle Health center
Arba Minch, South Ethiopia, Ethiopia Completed -
Birbir Primary Hospital
Birbir, South Ethiopia, Ethiopia Completed -
Laha Primary Hospital
Laha, South Ethiopia, Ethiopia Completed
Study contacts
- Study coordinator: Gistane Ayele
- Email: ayelegistane@yahoo.com
- Phone: _251925347903
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
FAP PET/CT in adults with pulmonary TB
This early-phase study tests whether a FAP PET/CT scan can map lung fibrosis in adults with pulmonary TB before starting treatment and after cure.
-
Sorfequiline-based regimens for adults with newly diagnosed drug-sensitive pulmonary TB
This study tests two sorfequiline-containing regimens, each with pretomanid and linezolid, to see if they are safe and effective in adults with newly diagnosed drug-sensitive pulmonary TB.
-
Ear acupuncture to reduce nausea and vomiting from tuberculosis medicines
This trial will test whether press-needle ear acupuncture can reduce nausea and vomiting in people taking medicines for pulmonary tuberculosis.
-
18F-FAPI-74 PET imaging for lung fibrosis in tuberculosis
This project tries to see if 18F-FAPI-74 PET scans can detect lung fibrosis in adults with active or recently treated tuberculosis.
-
Blood TB DNA test to track treatment progress
This project will test whether levels of TB-derived cell-free DNA in the blood can track treatment response in adults newly diagnosed with tuberculosis.
-
ID93+GLA‑SE vaccine for tuberculosis prevention in adults 55–74
This study will try three doses of the ID93+GLA‑SE vaccine to see if they are safe and boost immune responses in BCG‑vaccinated adults aged 55–74 compared with a saline placebo.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.