Digital group intervention to prevent perinatal depression

IMAGINE: Pilot Trial of a Digital Group Intervention to Prevent Perinatal Depression

NA · University of Washington · NCT06746337

This study tests a new online group program to see if it can help pregnant women and new moms at risk for depression feel better compared to standard care.

Quick facts

PhaseNA
Study typeInterventional
Enrollment100 (estimated)
Ages16 Years and up
SexFemale
SponsorUniversity of Washington (other)
Locations1 site (Seattle, Washington)
Trial IDNCT06746337 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the IMAGINE digital group intervention aimed at preventing depression in perinatal populations. Participants will be randomized to either the IMAGINE group for 12 weeks or receive standard care, with assessments of depression scores and intervention feasibility. The study will refine the intervention through qualitative feedback and measure its effectiveness in engaging cognitive behavioral therapy targets. The trial will include participants who are pregnant or up to 6 months postpartum and at elevated risk for perinatal depression.

Who should consider this trial

Good fit: Ideal candidates are individuals who are pregnant or up to 6 months postpartum, aged 16 or older, and at elevated risk for perinatal depression.

Not a fit: Patients currently experiencing major depression or those not at elevated risk for perinatal depression may not benefit from this intervention.

Why it matters

Potential benefit: If successful, this intervention could significantly reduce the incidence of perinatal depression among at-risk populations.

How similar studies have performed: Other studies have shown promise in using digital interventions for mental health, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pregnant or up to 6 months postpartum
* Age 16 or over
* At elevated risk of perinatal depression (per USPSTF)
* Speaks English or Spanish
* PHQ9\<15 and no current major depression
* Access to a smartphone with cellular data at least 3 days per week
* If receiving other mental healthcare services, has been established in care at least 6 months and on stable treatment regimen

Exclusion Criteria: none

Where this trial is running

Seattle, Washington

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Depression During Pregnancy, Depression, Postpartum, digital, perinatal, depression

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.