Digital detection methods for Alzheimer's disease and related dementias
Digital Detection of Dementia (D Cubed) Studies: D3
This study is testing if new digital tools can help doctors in primary care spots find and diagnose Alzheimer's disease and related dementias earlier in a diverse group of patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 3150 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Indiana University Academic / other |
| Locations | 1 site (Boca Raton, Florida) |
| Trial ID | NCT06224205 on ClinicalTrials.gov |
What this trial studies
This pragmatic trial aims to evaluate the effectiveness of a Passive Digital Marker (PDM) and a Quick Dementia Rating System (QDRS) in improving the rate of new documented diagnoses of Alzheimer's disease and related dementias (ADRD) in primary care settings. The study addresses the significant issue of underdiagnosis in ADRD, where many individuals go undiagnosed for years. By utilizing scalable and low-cost digital approaches, the trial seeks to enhance early detection and facilitate timely intervention for patients. The trial will be conducted in Eskenazi Health in central Indiana and will include diverse patient populations.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 65 years or older who have visited a primary care practice within the past year and can provide informed consent.
Not a fit: Patients with a prior diagnosis of Alzheimer's disease, mild cognitive impairment, or serious mental illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier and more accurate diagnoses of Alzheimer's disease and related dementias, improving patient outcomes and care planning.
How similar studies have performed: Other studies have shown promise in using digital tools for early detection of cognitive decline, but this specific approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 65 years or older * At least one visit to primary care practice within the past year * Ability to provide informed consent * Ability to communicate in English or Spanish * Available EHR data from at least the past three years Exclusion Criteria: * Prior ADRD or mild cognitive impairment diagnosis as determined by ICD-10 code * Evidence of any history of prescription for a cholinesterase inhibitors or memantine. * Has serious mental illness such as bipolar or schizophrenia as determined by ICD-10 code * Permanent resident of a nursing facility
Where this trial is running
Boca Raton, Florida
- University of Miami School of Medicine — Boca Raton, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Malaz Boustani, MD, MPH — Indiana University
- Study coordinator: Malaz Boustani, MD, MPH
- Email: mboustan@iu.edu
- Phone: 317-274-8536
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.