Diffusion-weighted MRI with MRCP to detect tumor-related biliary blockages

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses diffusion-weighted magnetic resonance imaging (DW-MRI) combined with MRCP as a non-invasive approach to differentiate malignant from benign biliary obstructions. Adults with clinically suspected biliary obstruction who are scheduled for MRCP and subsequent ERCP or biopsy will undergo DW-MRI and review of prior ultrasound or CT. Diagnostic performance of DW-MRI will be compared to the gold standards of ERCP findings and histopathology, with follow-up verification when available. Results will be analyzed to report sensitivity, specificity, and overall accuracy for detecting neoplastic biliary obstruction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years) with clinically suspected biliary obstruction (e.g., jaundice, elevated liver enzymes, cholestasis).
* Patients who are scheduled for magnetic resonance cholangiopancreatography (MRCP) and have undergone conventional imaging \[ultrasound or computed tomography (CT)\].
* Patients who will undergo further invasive procedures, e.g., endoscopic retrograde cholangiopancreatography (ERCP), biopsy.

Exclusion Criteria:

* Patients with contraindications to magnetic resonance imaging (MRI) (e.g., pacemakers, metal implants).
* Patients who have previously undergone major biliary surgery or stent placement.
* Pregnant or lactating women.

Where it's running

• General Authority for Teaching Hospitals and Institutes
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Hekmat S Baumey, MD
• Email: hekmattsamir@gmail.com
• Phone: 00201555433546

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.