Different volumes of the M-TAPA nerve block for pain after sleeve gastrectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center prospective randomized trial will enroll 60 adults scheduled for elective laparoscopic sleeve gastrectomy and randomize them to receive bilateral ultrasound-guided modified thoracoabdominal perichondrial approach (M-TAPA) blocks with three different volumes of 0.25% bupivacaine (20, 30, or 40 mL per side). Blocks are performed after induction of standardized general anesthesia and all patients receive standard intraoperative monitoring and postoperative care. Primary outcomes include postoperative pain scores and opioid consumption, with safety and recovery metrics tracked as secondary outcomes. Patients with ASA >2, chronic opioid use, prior major abdominal surgery, coagulopathy, local infection, or relevant neurologic or psychiatric disorders are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria

Patients will be eligible for the study if they meet the following criteria:

1. Adults aged \> 20 years to 60 years.
2. Scheduled for elective laparoscopic sleeve gastrectomy. Exclusion Criteria

Patients will be excluded from the study if any of the following conditions apply:

1. American Society of Anesthesiology (ASA) ASA \> class 2.
2. History of chronic pain or opioid use for more than 3 months before surgery.
3. Previous major abdominal surgery (which may affect M-TAPA efficacy).
4. Known hypersensitivity or allergy to local anesthetics (e.g., bupivacaine).
5. Coagulopathy or ongoing anticoagulant therapy that could increase bleeding risk.
6. Local infection at the injection site.
7. Neuromuscular disorders affecting pain perception.
8. Patient with mental or psychiatric disorders.

Where it's running

• Menofia faculty of medicine
  Shibīn al Kawm, Menofia, Egypt Recruiting

Study contacts

• Principal investigator: Ahmed Mohamed elkhouly, bachelor — Menoufia University
• Study coordinator: Ahmed Mohamed Elkhouly, bachelor's degree
• Email: xahmed035@gmail.com
• Phone: +201017829302

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.