Different spinal morphine doses for pain relief after hip replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults having elective total hip replacement receive spinal bupivacaine combined with varying doses of intrathecal morphine and standardized postoperative multimodal analgesia, including acetaminophen, an NSAID or metamizole, and PCA IV oxycodone as needed. The study tracks pain scores, opioid consumption, and adverse events—with particular attention to respiratory depression—primarily during the first 24 hours after surgery. Eligible participants are ASA I–III with BMI 19–30, able to use a PCA pump, and without chronic preoperative opioid use or contraindications to spinal anesthesia. The goal is to find a morphine dose that prolongs pain relief while minimizing serious side effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Informed consent to participate in trial
* Qualification for total hip replacement surgery
* ASA physical status I-III
* BMI 19-30
* Lack of contraindications for drugs and interventions used in trial

Exclusion Criteria:

* Incapability to provide informed consent
* Contraindications for spinal anesthesia
* Preoperative chronic pain
* Chronic use of analgesics
* Obesity (BMI\>30)
* Allergies and other contraindications for drugs used in trial
* Mental or physical incapability to operate PCA syringe pump

Where it's running

• Wojewódzki Szpital Specjalistyczny nr 5 im. św. Barbary
  Sosnowiec, Silesian Voivodeship, Poland Recruiting
• Zespół Opieki Zdrowotnej w Końskich
  Gmina Końskie, Świętokrzyskie Voivodeship, Poland Recruiting
• Uniwersytecki Szpital Kliniczny nr 1 im. prof. Tadeusza Sokołowskiego PUM w Szczecinie
  Szczecin, West Pomeranian Voivodeship, Poland Not yet recruiting

Study contacts

• Study coordinator: Szymon Białka, MD PhD
• Email: szymon.bialka@gmail.com
• Phone: +48323407593

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.