Different mixtures of lidocaine and bupivacaine for epidural anesthesia in lower limb surgery
Official title: Comparison of the Outcomes of Epidural Injection of Different Lidocaine-Bupivacaine Mixtures for Lower Limb Surgeries at a Tertiary Care Hospital, Karachi
Run by Shaheed Mohtarma Benazir Bhutto Institue of Trauma · NCT07648784 · Data updated 2026-11-12
This trial tests three lidocaine-bupivacaine epidural mixtures to see which gives the fastest, longest-lasting anesthesia with stable blood pressure for adults having lower limb surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 60 Years |
| Sex | All |
| Enrollment | 96 (estimated) |
| Sponsor | Shaheed Mohtarma Benazir Bhutto Institue of Trauma Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Status | Recruiting |
| Started | December 18, 2025 |
| Main results expected | May 20, 2026 |
| Study ends | June 15, 2026 |
| Registry record updated | June 15, 2026 |
| Trial ID | NCT07648784 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 20-60 years old, ASA I-II, undergoing lower limb surgery with planned epidural anesthesia, able to provide informed consent.
✕Probably not a fit
Patients with contraindications to regional anesthesia, emergencies, allergies to local anesthetics, spine deformities, or pregnancy may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, controlled trial compares three epidural anesthetic mixtures in adults aged 20-60 undergoing lower limb surgery at a tertiary care hospital in Karachi. Participants are randomly assigned to one of three groups with varying lidocaine and bupivacaine combinations to assess onset time, duration of anesthesia, and intraoperative hemodynamic stability. Primary aims are to identify which mixture provides optimal anesthesia for surgery and effective postoperative pain relief. The study uses standard epidural techniques and monitors cardiovascular responses throughout the procedure. Results could inform the choice of epidural regimens to improve surgical conditions and patient comfort.
Why it matters
Potential benefit: If successful, the preferred mixture could offer faster onset, longer pain control, and stable blood pressure during lower limb surgery.
How similar studies have gone: Previous research supports epidural use of lidocaine and bupivacaine for effective anesthesia, but direct comparisons of specific mixtures like these are less established and evidence is emerging.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients undergoing lower limb surgeries under epidural block Age between 20-60 years Either gender American Society of Anesthesiologists (ASA) physical status I and II Patients willing to provide informed consent Exclusion Criteria: Contraindications to regional anesthesia including patient refusal and bleeding diathesis History of allergy to local anesthetics Patients undergoing emergency surgeries Deformities of the spine History of hypothyroidism or hyperthyroidism Pregnant patients
Where it's running
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Shaheed Mohtarma Benazir Bhutto Institute of Trauma
Karachi, Sindh, Pakistan Recruiting
Study contacts
- Study coordinator: Tooba Azfar Hussain, MBBS
- Email: toobster1996@gmail.com
- Phone: 03357192306
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.