Different methods of connecting the pancreas to the intestine after surgery
A Prospective Randomized Controlled Trial of the Effect of Different Pancreaticojejunostomy After Pancreaticoduodenectomy on Postoperative Pancreatic Fistula Based on the Position of the Pancreatic Duct in Pancreatic Section
This study is testing different ways to connect the pancreas to the intestine after surgery to see if it can help prevent serious complications for patients recovering from pancreatic surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 924 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | West China Hospital Academic / other |
| Locations | 1 site (Chengdu, Sichuan) |
| Trial ID | NCT05475275 on ClinicalTrials.gov |
What this trial studies
This study aims to reduce the occurrence of postoperative pancreatic fistula (POPF) following pancreaticoduodenectomy by exploring various pancreaticojejunostomy techniques based on the anatomical position of the pancreatic duct. The research focuses on understanding how the duct's location influences the risk of developing POPF, a serious complication that can hinder recovery and lead to severe health issues. By categorizing the pancreatic ducts into central and eccentric types, the study seeks to identify optimal surgical approaches that minimize complications. The findings could provide valuable insights into improving surgical outcomes for patients undergoing this complex procedure.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old with a clinical diagnosis of benign or malignant peri-ampullary diseases who can tolerate surgery.
Not a fit: Patients undergoing simultaneous surgery on other organs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce the incidence of postoperative pancreatic fistula, leading to improved recovery and outcomes for patients undergoing pancreaticoduodenectomy.
How similar studies have performed: While there have been various studies on pancreatic fistula risk factors, this approach focusing on the anatomical position of the pancreatic duct is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of benign or malignant peri-ampullary diseases * The participants have age more than18 years * The participants have adequate organ function to tolerate surgery Exclusion Criteria: \*The participants undergoing other organ surgery at the same time
Where this trial is running
Chengdu, Sichuan
- Bole Tian — Chengdu, Sichuan, China (Recruiting)
Study contacts
- Study coordinator: Bole Tian, MD
- Email: hxtbl0338@163.com
- Phone: 86-28-85422474
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.