Different forms of IgE in health and disease.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study that collects blood samples from adult patients with various IgE‑related conditions and from age‑ and gender‑matched healthy controls at UZ/KU Leuven. Researchers will profile IgE proteoforms (molecular variants of IgE) to compare patterns across clinical groups. Clinical history and laboratory information will be recorded to link proteoform patterns to disease features such as recent anaphylaxis or ongoing desensitization. No investigational treatments are given; the focus is molecular characterization of patient samples.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* CSU and type I allergic diseases (including anaphylaxis and desensitization), atopic dermatitis, mastocytosis, XLA and HaT (informed consent, age: any available adult subject, gender: any available subject, clinical phenotype and specific information about the allergy (e.g. severity, medication, medical history, laboratory testing)
* Healthy controls (informed consent, age matched to the allergic patients, gender matched to the allergic patients, patient-reported symptoms related to allergy to aeroallergens, food, drugs, hymenoptera venom, CSU)

Exclusion Criteria:

* Absence of informed consent
* Age \< 18 years old

Where it's running

• UZ/KU Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Rik Schrijvers, MD, PhD — UZ/KU Leuven

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.