Dietary inflammation and gum health in adults with obesity
The Relationship Between Dietary Inflammatory Index and Periodontal Status in Obese Patients
This project will test whether a higher Dietary Inflammatory Index (how pro-inflammatory your usual diet is) is linked to worse gum disease and inflammatory markers in adults with obesity.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Recep Tayyip Erdogan University Training and Research Hospital Academic / other |
| Locations | 1 site (Rize) |
| Trial ID | NCT07287553 on ClinicalTrials.gov |
What this trial studies
This observational study will enroll 200 adults aged 18–65 with obesity and no other systemic diseases, who are non-smokers and not pregnant or lactating. Participants' diets will be scored using the Dietary Inflammatory Index (DII) and divided into four equal groups from low (anti-inflammatory) to high (pro-inflammatory) DII. Periodontal examinations will record standard indices and gingival crevicular fluid plus blood samples will be collected to measure biomarkers including IL-1β, IL-10, total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde (MDA), glutathione (GSH), leptin, and adiponectin. The study will compare periodontal status and biomarker levels across DII quartiles to see if more pro-inflammatory diets are associated with greater periodontal inflammation.
Who should consider this trial
Good fit: Ideal participants are adults 18–65 with BMI >30 kg/m2 or waist circumference >100 cm for men and >90 cm for women, who are non-smokers, free of other systemic diseases, not pregnant or lactating, and have not recently used antibiotics, corticosteroids, anti-inflammatories, or received periodontal treatment or nutritional counseling.
Not a fit: People with other systemic diseases (e.g., diabetes, cardiovascular or kidney disease), current smokers, pregnant or lactating individuals, recent recipients of periodontal treatment or relevant medications, and those who are not obese are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, this work could help identify dietary patterns that contribute to gum inflammation in people with obesity and guide nutrition-based prevention or management strategies.
How similar studies have performed: Previous observational studies have reported links between pro-inflammatory diets, systemic inflammatory markers, and periodontal outcomes, but findings are mixed and causality has not been established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being diagnosed with obesity, * Not having any systemic conditions other than obesity (systemic diseases that may affect periodontal health, such as cardiovascular disease, chronic kidney disease, Type 1 diabetes, Type 2 diabetes, and hypertension (\>130/85 mmHg)), * Being between the ages of 18 and 65, * Not smoking or consuming alcohol, * Not having used anti-inflammatory medications in the last 3 months, or antibiotics or systemic corticosteroids in the last 6 months, * Not being pregnant or lactating, * Not having received periodontal treatment in the last 6 months, * Not having received nutritional advice in the last 3 months, * Obesity diagnosis: BMI \> 30 kg/m2 or waist circumference: \> 100 cm for men and \> 90 cm for women. Exclusion Criteria: * Non-obese * Having any systemic disease other than obesity (such as cardiovascular disease, chronic kidney disease, Type 1 diabetes, Type 2 diabetes, and hypertension (\>130/85 mmHg) that may affect periodontal health) * Being over 65 years old and under 18 years old * Smoking and alcohol use * Having used anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months * Being pregnant or lactating * Having received periodontal treatment in the last 6 months * Having received nutritional advice in the last 3 months
Where this trial is running
Rize
- Recep Tayyip Erdoğan University — Rize, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Hatice Yemenoglu
- Email: htcymnglu@hotmail.com
- Phone: +905052977517
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.