Dietary approaches to achieve remission in Type 2 Diabetes
DECIDE: DiEt ChoIce to Promote Type 2 Diabetes REmission Supported by Community Pharmacists and Registered Dietitians
This study is testing if low-calorie and low-carb diets can help people with Type 2 Diabetes go into remission and improve their health over a year.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Kelowna, British Columbia) |
| Trial ID | NCT05710900 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of low-calorie and low-carbohydrate diets in promoting remission of Type 2 Diabetes (T2D). Participants will undergo a three-phase intervention focusing on weight loss, medication reduction, and transitioning to a sustainable dietary pattern over the course of one year. The study will assess patient preferences, adherence, satisfaction, and clinical outcomes, including remission rates and blood biomarkers. Qualitative feedback will also be gathered to identify barriers and facilitators to each dietary approach.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20-80 with a diagnosis of Type 2 Diabetes and a Body Mass Index of 27 kg/m2 or higher.
Not a fit: Patients with a history of significant cardiovascular issues, certain chronic diseases, or those with dietary restrictions that prevent adherence to the intervention may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-pharmacological approach to achieving remission in patients with Type 2 Diabetes.
How similar studies have performed: Previous studies have shown promising results with dietary interventions for Type 2 Diabetes remission, indicating that this approach is both relevant and potentially effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 20-80 years old * Diagnosed with T2D by a physician, * HbA1c ≥ 6.0%, * Body Mass Index ≥27 kg/m2 and * No contraindications or dietary restrictions to following a low-carbohydrate/low-calorie diet. Exclusion Criteria: * History of heart disease, heart attack, heart failure, stroke or coronary artery disease within the previous 2 years, * any current unstable cardiovascular disorder, * history of liver disease, * history of kidney disease with eGFR \<30 mls/min/1.73 m2, * history of neurological disease, * previous bariatric surgery, * weight loss (≥5%) within the last six months * currently pregnant or lactating, or planning on becoming pregnant within the next 12 months, * history of cancer within the previous 5 years, * dietary restrictions or allergies that would inhibit adherence to the intervention diet, * history of eating disorders, * moderate or severe depression, anxiety or mental health condition that impacts daily life, * currently following a low-carbohydrate or low-calorie diet, and * unable to access the Internet (for communication with research team and RD).
Where this trial is running
Kelowna, British Columbia
- University of British Columbia Okanagan — Kelowna, British Columbia, Canada (Recruiting)
Study contacts
- Study coordinator: Barbara Oliveira, PhD
- Email: barbara.oliveira@ubc.ca
- Phone: (250) 859-9900
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.