Diet to protect lungs from woodsmoke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Forty-eight healthy adults (24 male and 24 female at birth) who currently eat little fish and fewer than five servings of fruits and vegetables per day will be enrolled and required to have a null GSTM1 genotype. Participants will be supported to follow either a diet higher in fatty fish, fruits, and vegetables or a control diet while undergoing three controlled exposures (one filtered air and two woodsmoke) with repeated blood, urine, sputum, and lung function measurements. The protocol includes a screening visit plus 10 in-person visits at Vancouver General Hospital over about 15 weeks (≈34.5 hours on site), meal/grocery deliveries or subsidies, weekly 30-minute phone calls with a study dietitian, and some at-home electronic questionnaires and breathing tests. The team will compare biological and lung-function responses after woodsmoke exposures between the diet groups to see if the dietary pattern reduces harm.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy, and specifically with no respiratory disease
* Not taking any supplements, or willing to abstain from supplement use for 4-weeks prior to study start and the whole duration of the study,
* Must currently consume, on average, less than 2 servings of fish per week and fewer than 5 servings of fruits and vegetables per day based on screening questionnaires.
* Must have a null GSTM1 genotype determined at screening.
* Must be able to provide a sufficient sputum sample during the screening visit.

Exclusion Criteria:

* Pregnant or planning to become pregnant during the study period.
* Health conditions that would pose an unacceptable risk of dietary change, or conditions that are uncontrolled based on principal investigator's judgement.
* Actively attempting to lose weight.
* Frequent wood smoke exposure (e.g. at home or employment).
* Unable to store provided meals and food safely.
* Food allergies/intolerance or food aversion preventing adherence to the intervention diet, or unwillingness/medically unable to adjust diet in line with the intervention.
* Relocation during the study period to an area which will prevent food delivery.
* History of smoking tobacco, marijuana, or and other substance or vaping within the past 6 months, or having smoked the equivalent of 0.5 pack-years ever.
* Body mass index (BMI) \<18.5, as determined during the in-person screening visit.

Where it's running

• University of British Columbia
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Emily Brigham, MD — University of British Columbia
• Study coordinator: Agustin Bueso
• Email: agustin.bueso@ubc.ca
• Phone: 604-875-4111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How people use beans, peas, and lentils in meals

  This project will test how Americans who regularly cook choose beans, peas, and lentils when building mixed dishes and how they feel about eating them.

  Recruiting USDA Grand Forks Human Nutrition Research Center · Grand Forks, North Dakota · NCT07451119

• How blood flow restriction leg training affects muscles and blood markers

  This project tests if six weeks of blood flow restriction leg training changes muscle size and blood biomarkers in healthy adults aged 18–40, including both people new to strength training and experienced athletes.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar, Merkez · NCT07340385

• BLa80 and LRa05 probiotics and blood metabolite changes in healthy adults

  This test will see if taking the probiotics BLa80 or LRa05 changes how healthy adults break down and absorb food, as shown by metabolites in the blood.

  Recruiting Wecare Probiotics Co., Ltd. · Guangzhou, Guangdong · NCT07287306

• Heel-lift insole effects on lower limb and lower back motion

  This study will test whether wearing a heel lift insole changes muscle activity and movement angles of the lower limbs and lower back in healthy young adults.

  Recruiting Cairo University · Giza, Giza Governorate and 1 other locations · NCT07047300

• Trans-spinal magnetic stimulation to modulate cortical excitability in healthy adults

  We test whether different frequencies and intensities of trans‑spinal magnetic stimulation change motor cortex excitability in healthy adults aged 18–40.

  Recruiting Phase 1 Universidade Federal de Pernambuco · Recife, Pernambuco · NCT07026760

• Peripheral magnetic stimulation effects on motor‑cortex excitability in healthy adults

  This project will try different peripheral magnetic stimulation settings to see if they change motor‑cortex excitability in healthy adults aged 18–40.

  Recruiting Phase 1 Universidade Federal de Pernambuco · Recife, Pernambuco · NCT07025759

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.