Diaphragm movement and breathing drive in people with OSA, COPD, or both

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, cross-sectional study compares diaphragmatic structure and respiratory drive across four groups: OSA, COPD, overlap syndrome, and healthy controls. Participants will undergo overnight polysomnography, spirometry, impulse oscillometry, diaphragm ultrasound, and surface diaphragm EMG to measure thickness, excursion, thickening fraction, and EMGdi parameters (rest, max, %max). Investigators will compare group differences and examine relationships between diaphragmatic indicators and respiratory measures such as FEV1, FVC, AHI, and R5-R20. The aim is to identify objective diaphragmatic markers that could characterize dysfunction and help differentiate overlap syndrome.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged between 18 and 80 years.
2. For OSA Group: Diagnosed obstructive sleep apnea with AHI ≥ 5 events/hour based on overnight polysomnography.
3. For COPD Group: Diagnosed chronic obstructive pulmonary disease based on GOLD guidelines.
4. For Overlap Group: Diagnosed both OSA (AHI ≥ 5) and COPD.
5. For Control Group: Healthy volunteers with no known respiratory diseases or sleep disorders.
6. Ability and willingness to provide informed consent for participation in the study.

Exclusion Criteria:

1. Severe cardiovascular diseases (e.g., unstable angina, heart failure NYHA III/IV).
2. Severe hepatic or renal insufficiency.
3. Neuromuscular diseases affecting respiratory muscles.
4. Recent upper airway or thoracic surgery (within 3 months).
5. Pregnancy or breastfeeding.
6. Participants who cannot complete assessments due to cognitive impairment or poor cooperation.

Where it's running

• The First Affiliated Hospital of Nanjing Medical University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Ding Ning, doctor
• Email: dr.ningding@live.cn
• Phone: 86-25-68136723

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Multimodal Deep Learning to Predict Sleep Apnea Severity from SpO2 and Ballistocardiography

  Researchers are testing a smart-mattress-based method that uses SpO2 and ballistocardiography data to predict sleep apnea severity in adults undergoing overnight sleep study.

  Recruiting Fu Jen Catholic University · New Taipei City, New Taipei City · NCT07923825

• Nightly wearable monitoring with at-home submental electrical stimulation for sleep apnea

  This pilot test checks whether wearing a ring sensor at night and doing a 4-week at-home submental electrical stimulation is feasible for adults with obstructive sleep apnea and looks at changes in sleep metrics.

  Recruiting E-DA Hospital · Kaohsiung City · NCT07921329

• Functional capacity and muscle function in adults with obstructive sleep apnea

  This study tests how obstructive sleep apnea affects respiratory and peripheral muscle strength, endurance, and upper‑extremity function compared with healthy adults.

  Recruiting Karabuk University · Karabük · NCT07913139

• Transcutaneous Electrical Stimulation for Obstructive Sleep Apnea

  This study tests whether applying gentle electrical stimulation to the throat muscles at night can reduce sleep apnea severity in adults with obstructive sleep apnea.

  Recruiting Mansoura University · Al Mansurah, Dakahlia Governorate · NCT07891702

• Physical activity habits and sleep/ breathing in obstructive sleep apnea

  This study tests whether daily physical activity habits affect sleep quality and breathing measurements in people with obstructive sleep apnea who are on CPAP therapy.

  Recruiting Medipol University · Istanbul, Göztepe · NCT07889154

• CES-EES score and a wearable ring for diagnosing obstructive sleep apnea

  This study tests whether the CES-EES clinical score and the Belun Ring wearable can accurately diagnose obstructive sleep apnea without in-lab polysomnography in adults referred for suspected OSA.

  Recruiting University of Malaya · Pantai Valley, Kuala Lumpur · NCT07785999

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.