Diaphragm function after an interscalene block with liposomal bupivacaine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares two local anesthetic approaches for interscalene brachial plexus block in adults undergoing upper limb surgery. Group A receives 20 mL of 0.5% plain bupivacaine, while Group B receives 10 mL of 0.5% plain bupivacaine plus 10 mL of liposomal bupivacaine. Researchers will assess diaphragmatic and pulmonary function and pain at baseline and multiple time points after the block, with monitoring for adverse events. The study plans to enroll 120 participants and run from 2025 to 2026 under standard ethical and privacy protections. Outcomes focus on diaphragmatic preservation and respiratory impact alongside analgesia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing upper limb surgery scheduled for interscalene brachial plexus block
* Aged ≥ 18 years
* American Society of Anesthesiologists (ASA) physical status I-III

Exclusion Criteria:

* Known allergy or intolerance to amide local anesthetics
* Nerve injury in the upper limb on the surgical side
* Coagulopathy
* Used opioid medications continuously for more than 3 weeks before surgery
* History of pulmonary disease and a pulse oxygen saturation (SpO₂) \< 95% (measured after 5 minutes of rest at room temperature without oxygen supplementation, using a transcutaneous pulse oximeter)
* Refuse to participate or are deemed unsuitable for this trial by the researchers

Withdrawal Criteria:

* Patients voluntarily withdrew their informed consent
* Surgery was canceled or the anesthesia method was changed due to surgical factors before interscalene brachial plexus block

Where it's running

• The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, zhejiang 310000
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Diansan Su
• Email: diansansu@yahoo.com
• Phone: +8618616514088

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.