Diagnostic and surgical standards for cerebral tinnitus from internal jugular vein narrowing
Official title: Evaluation Criteria, Diagnostic Criteria, Surgical Indications, and Establishment of Surgical Standards for "Cerebral Tinnitus Syndrome" Caused by Internal Jugular Vein Stenosis.
Run by Beijing Shijitan Hospital, Capital Medical University · NCT07560280 · Data updated 2026-11-12
This trial will try a surgical procedure (atlas transverse process mastoidectomy with lysis and perfusion) to see if it relieves cerebral tinnitus symptoms in adults whose symptoms are linked to internal jugular vein stenosis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 369 (estimated) |
| Sponsor | Beijing Shijitan Hospital, Capital Medical University Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | May 7, 2025 |
| Main results expected | December 30, 2029 |
| Study ends | December 30, 2030 |
| Registry record updated | May 1, 2026 |
| Trial ID | NCT07560280 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 who have had Cerebral Tinnitus Syndrome symptoms for at least three months and imaging-confirmed internal jugular vein stenosis (≥50%) with other causes preliminarily excluded are the ideal candidates.
✕Probably not a fit
Patients without imaging-confirmed IJVS, those with other established causes of intracranial sounds, or those with severe systemic disease or prior relevant cranial surgery are unlikely to benefit from this surgical approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial enrolls adults with persistent symptoms of Cerebral Tinnitus Syndrome and imaging evidence of internal jugular vein stenosis (≥50%). After excluding other known causes, participants undergo atlas transverse process mastoidectomy with lysis and perfusion as the interventional treatment. The project aims to define diagnostic criteria, surgical indications, and standardized operative techniques for IJVS-related cerebral tinnitus. Outcomes and follow-up will be used to create systematic standards where current evidence is mostly limited to case reports.
Why it matters
Potential benefit: If successful, the approach could reduce tinnitus and related symptoms and provide clear diagnostic and surgical guidance for patients with IJVS-linked cerebral tinnitus.
How similar studies have gone: Existing literature on IJVS-related cerebral tinnitus is primarily case reports and small series, so systematic evidence and consistent success data are currently limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age between 18 and 75 years, with no gender restriction. 2. Presence of one or more symptoms associated with "Cerebral Tinnitus Syndrome," with a duration of at least 3 months. 3. Following a detailed medical history and comprehensive physical examination, other known causes of cerebral tinnitus are preliminarily excluded, with suspected internal jugular vein stenosis (IJVS) as the cause. 4. Imaging studies (e.g., jugular ultrasound, cervical venous CT venography (CTV)) show significant stenosis in the internal jugular vein (stenosis degree ≥50%). 5. The patient has provided informed consent and voluntarily agrees to participate in the study, with a signed informed consent form. Exclusion Criteria: 1. Patients with a history of cranial surgery or diagnosed intracranial space-occupying lesions. 2. Patients with severe cardiac, hepatic, or renal insufficiency, or other systemic diseases. 3. Patients who have undergone any surgical or interventional procedures affecting jugular venous flow within the last 6 months. 4. Patients with a history of psychiatric disorders or cognitive impairment who cannot complete study evaluations. 5. Pregnant or breastfeeding women.
Where it's running
-
Beijing Shijitan Hospital, Capital Medical University
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Zhiqiang Hu
- Email: neuro7@163.com
- Phone: 86+13501378609
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Muscle strength and joint flexibility in elite artistic swimmers across age groups
This project will test whether elite Spanish artistic swimmers in infant, junior, and senior categories have distinct joint mobility and isometric strength profiles that could help guide training and prevent injuries.
-
Checking if the Postural Habits and Awareness Scale (PHAS) works well for people with postural hyperkyphosis.
This project will test whether the Postural Habits and Awareness Scale (PHAS) gives consistent results for people aged 8 to 65 with postural hyperkyphosis.
-
Video-based self-check for neonatal resuscitation skills in fourth-year midwifery students
This study tests whether watching and reflecting on videos of their own neonatal resuscitation practice helps fourth-year midwifery students improve skills, judgment, satisfaction, and confidence.
-
Evaluating a new blood self-collection device for diagnostic tests
This study is testing a new device that lets people collect their own blood samples at home to see if it works as well as traditional blood draws done in a clinic.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.