Diagnosing diabetes in patients with Dunnigan's syndrome using a carbohydrate breakfast
Assess the Possibility of Diagnosing Diabetes and Rediabetes Following Oral Induced Hyperglycemia in Patients With Dunnigan's Partial Familial Lipodystrophy by Replacing 75 g of Glucose With a Standardized Carbohydrate Breakfast and Continuous Interstitial Monitoring Glucose)
This study is testing if a special carbohydrate breakfast can help diagnose diabetes in people with Dunnigan's syndrome, focusing on those from Réunion who have a unique genetic variant.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de la Réunion Academic / other |
| Locations | 1 site (Saint-Denis) |
| Trial ID | NCT05789251 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the possibility of diagnosing diabetes and prediabetes in patients with Dunnigan's partial familial lipodystrophy by replacing the traditional 75 g glucose load with a standardized carbohydrate breakfast. The approach involves continuous interstitial glucose monitoring to evaluate metabolic responses. The study focuses on patients from Réunion, where a unique variant of the LMNA gene is prevalent, leading to severe insulin resistance and early diabetes. Annual follow-ups with oral glucose tolerance tests (OGTT) are recommended for non-diabetic subjects to detect metabolic complications early.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 18 to 75 with Dunnigan's partial familial lipodystrophy who are not known to be diabetic.
Not a fit: Patients who are already diagnosed with diabetes or those scheduled for scans within a week of glucose monitoring will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective method for early diagnosis of diabetes in patients with Dunnigan's syndrome.
How similar studies have performed: While there is limited information on similar studies specifically for Dunnigan's syndrome, the approach of using alternative methods for glucose monitoring has shown promise in other metabolic conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject with Dunnigan's partial familial lipodystrophy followed at Reunion University Hospital not known to be diabetic. Aged 18 to 75 Having given their informed consent. Exclusion Criteria: * Diabetic patient Patient scheduled for scan within 7 days of freestyle placement protected persons: "pregnant woman, parturient, nursing mother, person deprived of liberty by judicial or administrative decision, minor, and person subject to a measure of legal protection: guardianship or curatorship)"
Where this trial is running
Saint-Denis
- Centre Hospitalier Universitaire de La Réunion — Saint-Denis, Reunion (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.