Development of MRI techniques for lung imaging in healthy volunteers
Healthy Lung Study- Development of 3 Tesla MRI Hardware and Software for Helium-3 Gas Imaging of the Lung: Healthy Volunteer Development Study
This study is testing new MRI techniques for lung imaging in healthy volunteers to see how well they work and if they can be used reliably.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Western University, Canada Academic / other |
| Locations | 1 site (London, Ontario) |
| Trial ID | NCT03169673 on ClinicalTrials.gov |
What this trial studies
This observational study involves healthy volunteers aged 18-75 who will undergo hyperpolarized 3-Helium MRI and pulmonary function testing. Participants will complete a series of assessments including medical history, vital signs, and various pulmonary function tests, followed by MRI scans to evaluate imaging techniques. The goal is to develop tools for assessing image quality and reproducibility in lung imaging. The study will take place at the Pulmonary Function Laboratory at Robarts Research Institute.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals aged 18-75 with a BMI between 18 and 40 and a minimal smoking history.
Not a fit: Patients with significant health issues, respiratory conditions, or those unable to undergo MRI due to physical constraints will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance imaging techniques for lung assessment, potentially leading to better diagnosis and monitoring of pulmonary conditions.
How similar studies have performed: While the use of hyperpolarized 3-Helium MRI is a novel approach, similar imaging techniques have shown promise in other studies, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to perform a breath hold for up to 16 seconds. * BMI between 18 and 40. * Stable health on the basis of medical history. * Smoking history \< 1 pack/year. Exclusion Criteria: * Patient is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material. * Subject has a daytime room air oxygen saturation \<90% while lying supine. * Patient is unable to perform spirometry or plethysmography maneuvers * Patient is pregnant * In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia. * Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants.)
Where this trial is running
London, Ontario
- Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre — London, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Grace E Parraga, PhD — Study Principal Investigator Robarts Research Institute, The University of Western Ontario
- Study coordinator: Grace E Parraga, PhD
- Email: gparraga@robarts.ca
- Phone: 519-931-5265
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.