Developing tests for precise diagnosis of age-related hearing loss
Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss
NA · Institut Pasteur · NCT05312983
This study is testing new hearing tests to better diagnose age-related hearing loss in older adults so they can get the right treatment sooner.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 700 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Institut Pasteur (industry) |
| Locations | 2 sites (Paris and 1 other locations) |
| Trial ID | NCT05312983 on ClinicalTrials.gov |
What this trial studies
This project aims to create a comprehensive battery of audiological tests to accurately diagnose age-related hearing loss, known as presbycusis. It involves a multi-center, non-invasive case-control study with 700 participants, including 500 individuals with anticipated presbycusis and 200 healthy controls. Participants will undergo extensive audiological, vestibular, and neurocognitive assessments over multiple visits, along with genetic analysis through blood sampling. The goal is to enhance early identification and treatment of hearing loss through tailored hearing aid adjustments.
Who should consider this trial
Good fit: Ideal candidates include individuals over 40 with anticipated presbycusis or those aged 18-40 with a progressive genetic hearing defect.
Not a fit: Patients with chronic exposure to loud sounds, history of ototoxic substance use, or other significant ear-related health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and personalized treatment plans for patients with age-related hearing loss.
How similar studies have performed: Other studies have shown promise in developing diagnostic tools for hearing loss, but this approach is innovative in its focus on precision diagnosis through a comprehensive test battery.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For all participants: * Be over the age of 18, * Be affiliated to a social security system, * Have a good command of the French language (oral and written). For the group of participants with anticipated presbycusis: * Over the age of 40, having a hearing aid recipient or coming for a first hearing aid recipient * Between 18 and 40, having a hearing aid recipient, coming for a first hearing aid recipient or declare a progressive genetic birth defect For healthy volunteers: \- Have no known hearing loss. Exclusion Criteria: * Report having been chronically exposed to loud sounds. * Have a history of ototoxic substances, * To have sequelae of ear infections and/or a history of ENT disease that permanently affects hearing or balance, * Have an ethnic origin for which the Pasteur Institute does not have information on the frequency of variants of the genes studied. * Have type II diabetes, * Have a neurological or psychiatric condition that interferes with comprehension or ability to move, * Be under guardianship, * Be deprived of liberty by judicial or administrative decision, or be subject to legal protection, * Not being subject to a social security system, * Taking narcotic substances, alcohol or medication that diminishes cognitive abilities.
Where this trial is running
Paris and 1 other locations
- Laboratoire de correction auditive — Paris, France (NOT_YET_RECRUITING)
- CEntre de Recherche et d'Innovation en Audiologie Humaine — Paris, France (RECRUITING)
Study contacts
- Principal investigator: Paul Avan, MD — CERIAH
- Study coordinator: Celine Quinsac
- Email: celine.quinsac@pasteur.fr
- Phone: +33 (0)1 76 53 50 29
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Presbyacusis, presbyacusis, aging, audiology, genetic