Developing tests for precise diagnosis of age-related hearing loss

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to create a comprehensive battery of audiological tests to accurately diagnose age-related hearing loss, known as presbycusis. It involves a multi-center, non-invasive case-control study with 700 participants, including 500 individuals with anticipated presbycusis and 200 healthy controls. Participants will undergo extensive audiological, vestibular, and neurocognitive assessments over multiple visits, along with genetic analysis through blood sampling. The goal is to enhance early identification and treatment of hearing loss through tailored hearing aid adjustments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For all participants:

* Be over the age of 18,
* Be affiliated to a social security system,
* Have a good command of the French language (oral and written).

For the group of participants with anticipated presbycusis:

* Over the age of 40, having a hearing aid recipient or coming for a first hearing aid recipient
* Between 18 and 40, having a hearing aid recipient, coming for a first hearing aid recipient or declare a progressive genetic birth defect

For healthy volunteers:

\- Have no known hearing loss.

Exclusion Criteria:

* Report having been chronically exposed to loud sounds.
* Have a history of ototoxic substances,
* To have sequelae of ear infections and/or a history of ENT disease that permanently affects hearing or balance,
* Have an ethnic origin for which the Pasteur Institute does not have information on the frequency of variants of the genes studied.
* Have type II diabetes,
* Have a neurological or psychiatric condition that interferes with comprehension or ability to move,
* Be under guardianship,
* Be deprived of liberty by judicial or administrative decision, or be subject to legal protection,
* Not being subject to a social security system,
* Taking narcotic substances, alcohol or medication that diminishes cognitive abilities.

Where it's running

• CEntre de Recherche et d'Innovation en Audiologie Humaine
  Paris, France Recruiting
• Laboratoire de correction auditive
  Paris, France Not yet recruiting

Study contacts

• Principal investigator: Paul Avan, MD — Ceriah
• Study coordinator: Celine Quinsac
• Email: celine.quinsac@pasteur.fr
• Phone: +33 (0)1 76 53 50 29

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.