Developing prediction models for sarcoidosis progression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to create prediction models that assess the risk of progression in patients with pulmonary sarcoidosis. By utilizing clinical data and blood markers collected during routine clinic visits, the study seeks to identify key clinical features and biomarkers that can indicate disease evolution. The primary objective focuses on determining which clinical characteristics are associated with disease progression, while the secondary objective evaluates the potential of specific blood biomarkers to enhance risk assessment. The study will involve adults diagnosed with sarcoidosis and will follow established diagnostic criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults with a diagnosis of sarcoidosis over the age of 18
2. Case definition: we will follow the 1999 statement on sarcoidosis published by the American Thoracic Society for diagnosis which includes tissue biopsy confirmation and exclusion of alternative diagnoses including beryllium sensitization/chronic beryllium disease, mycobacterial, viral, and/or fungal infection

Exclusion Criteria:

1. Inability to tolerate study procedures as determined by the investigator
2. Pregnant or breastfeeding
3. Concurrent medical diagnoses that would influence the expression of biomarkers will be considered an exclusion criterion. This includes diseases such as common variable immunodeficiency, HIV infection, or autoimmune diseases
4. Concurrent interstitial lung diseases such as hypersensitivity pneumonitis or idiopathic pulmonary fibrosis
5. Hematocrit (Packed Cell Volume) \< 25%

Where it's running

• University of Maryland
  Baltimore, Maryland, United States Recruiting
• UT Southwestern
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Laura Koth — University of California, San Francisco
• Study coordinator: Laura Koth
• Email: laura.koth@ucsf.edu
• Phone: 4155144369

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.