Developing MRI biomarkers for juvenile arthritis
The Development and Validation of Quantitative Imaging Biomarkers as a Measure of Disease Activity in Juvenile Idiopathic Arthritis
University College London Hospitals · NCT02684695
This study is trying to see if MRI scans can help track how active juvenile idiopathic arthritis is in young people aged 12-24.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 12 Years to 24 Years |
| Sex | All |
| Sponsor | University College London Hospitals (other) |
| Locations | 1 site (London) |
| Trial ID | NCT02684695 on ClinicalTrials.gov |
What this trial studies
This observational study aims to develop and validate quantitative magnetic resonance imaging (MRI) biomarkers to measure disease activity in juvenile idiopathic arthritis (JIA), including enthesitis-related arthritis. Patients aged 12-24 with a diagnosis of JIA will undergo MRI scans as part of their routine clinical care. The study will also include control subjects with mechanical back pain to provide a comparative analysis. The research will consist of several sub-studies focused on the effectiveness of MRI in assessing JIA.
Who should consider this trial
Good fit: Ideal candidates are adolescents and young adults aged 12-24 diagnosed with juvenile idiopathic arthritis or enthesitis-related arthritis.
Not a fit: Patients who are unable to undergo MRI scans due to contraindications or those with conditions unrelated to juvenile arthritis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for monitoring and managing juvenile arthritis.
How similar studies have performed: Other studies have shown promise in using MRI for assessing arthritis, but this specific approach is novel in its focus on quantitative biomarkers for JIA.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * For cases, patients will have clinical diagnosis of JIA: enthesitis-related arthropathy, extended oligoarthritis or polyarthritis (defined according to ILAR criteria) * For controls, patients will have a diagnosis of mechanical back pain (though to arise from muscles, bones, ligaments or discs), with normal inflammatory markers * Age 12-24 Exclusion Criteria: * Contra-indication to MRI scan (e.g. metal foreign object) * Unable to give consent * Unable to speak English * Unable to tolerate an MRI scan (e.g. due to claustrophobia, contrast allergy) * Renal or hepatic failure (eGFR \< 30ml/min for renal failure, where applicable)
Where this trial is running
London
- University College London Centre for Medical Imaging — London, United Kingdom (RECRUITING)
Study contacts
- Study coordinator: Timothy JP Bray, MBBChir
- Email: t.bray@ucl.ac.uk
- Phone: 0203 447 9324
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Arthritis, Juvenile Idiopathic, Enthesitis-Related Arthritis, Juvenile, Magnetic resonance imaging, Imaging biomarker, Diffusion-weighted imaging