Developing cell models to study hearing mechanisms
Development of Cellular Models of the Ear and Nose From Patient Samples to Study the Mechanisms of Hearing
University Hospital, Brest · NCT04823195
This study is trying to create cell models from the ear and nose to see how certain genes might be linked to hearing loss in older adults.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | University Hospital, Brest (other) |
| Locations | 1 site (Brest) |
| Trial ID | NCT04823195 on ClinicalTrials.gov |
What this trial studies
This study focuses on creating cell cultures derived from the ear and nose to investigate the mechanisms underlying hearing loss, particularly in patients with early presbycusis. By examining the cis-regulation of the GJB2 gene, the research aims to identify genetic factors contributing to hearing impairment. The observational nature of the study allows for the collection of data without direct intervention, providing insights into auditory mechanisms. The findings could enhance understanding of hearing loss and inform future therapeutic strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals experiencing presbycusis-related hearing loss.
Not a fit: Patients with genetic forms of hearing loss may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for hearing loss.
How similar studies have performed: While similar studies have explored genetic factors in hearing loss, this specific approach using cell models is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hearing loss Presbycusis Exostosis Exclusion Criteria: * Genetic hearing loss
Where this trial is running
Brest
- CHRU de Brest — Brest, France (RECRUITING)
Study contacts
- Study coordinator: Rémi Marianowski
- Email: remi.marianowski@chu-brest.fr
- Phone: 02-98-22-33-78
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hearing Loss, GJB2, Cis Regulation, DFNB1