Determining the best time to stop CPAP for premature infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the optimal timing for weaning Continuous Positive Airway Pressure (CPAP) in extremely low birth weight infants born before 30 weeks of gestation. It is a multicenter, non-blinded, randomized control trial conducted across four Neonatal Intensive Care Units (NICUs) within the Rady Children's/University of California, San Diego network. The study aims to recruit 130 infants and will compare the duration of respiratory support and oxygen exposure between those following a structured weaning protocol and those weaned earlier. The goal is to reduce CPAP weaning failure rates and improve outcomes for these vulnerable infants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. All infants admitted to the NICU at Jacobs, Rancho Springs, Scripps La Jolla, Rady Children's Hospital, or Palomar born at \< 30 weeks CGA
2. Informed parental consent obtained

Exclusion Criteria:

1. Declined or unable to give informed consent
2. Infants with known congenital anomalies or complications that require long term support (pulmonary hypoplasia, airway defects, genetic syndromes, necrotizing enterocolitis (NEC), spontaneous intestinal perforation (SIP), anything surgical)
3. Intubated for over 4 weeks of life (28 days)

Where it's running

• Palomar Medical Center Rady NICU
  Escondido, California, United States Recruiting
• Scripps La Jolla Rady NICU
  La Jolla, California, United States Recruiting
• University of California, San Diego Jacobs Medical Center
  La Jolla, California, United States Recruiting
• Rancho Springs Medical Center Rady NICU
  Murrieta, California, United States Recruiting
• Rady Children's Hospital-San Diego
  San Diego, California, United States Recruiting

Study contacts

• Principal investigator: Sandra Leibel, MD — University of California, San Diego
• Study coordinator: Sandra Leibel, MD
• Email: saleibel@health.ucsd.edu
• Phone: 858-249-1702

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.