Determining the best dexamethasone dose for knee surgery
Corticosteroids in Total Knee Arthroplasty: How Many Dexamethasone Doses Should Be Given Perioperatively? A Randomized Controlled Trial
This study is testing the best dose of dexamethasone for people having knee surgery to see if it can help reduce pain and the need for opioids while also lowering side effects like nausea.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 339 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06715709 on ClinicalTrials.gov |
What this trial studies
This study aims to identify the optimal and safest dose of dexamethasone administered perioperatively during total knee arthroplasty to reduce postoperative opioid consumption and pain, while also minimizing nausea, vomiting, and complications. It utilizes a multimodal analgesia approach, focusing on decreasing reliance on opioids and enhancing patient satisfaction post-surgery. The study will compare different administration methods of dexamethasone, including intravenous and oral routes, to evaluate their effectiveness in improving recovery outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old scheduled for primary total knee arthroplasty.
Not a fit: Patients who have had recent corticosteroid use, inflammatory arthritis, or other specified medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management and faster recovery for patients undergoing total knee arthroplasty.
How similar studies have performed: Previous studies have shown that corticosteroids can effectively reduce postoperative pain and nausea, indicating a promising approach in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Age \> 18 years * Primary total knee arthroplasty Exclusion Criteria * Age \< 18 year * Revision or unicompartmental knee arthroplasty * Corticosteroid use within 3 months prior to TKA * Inflammatory arthritis * Current systemic fungal infection * Renal or liver failure * Prior adverse reaction to corticosteroid * Primary TKA requiring hardware removal
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Charles Hannon — Mayo Clinic
- Study coordinator: Erin Hennessey
- Email: hennessey.erin@mayo.edu
- Phone: 507-284-1975
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.