Detecting urinary exosomes in patients with clear cell renal cell carcinoma
Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma
Centre Hospitalier Universitaire de Saint Etienne · NCT04053855
This study is testing a new way to find cancer markers in urine from patients with clear cell kidney cancer to see if it can help with early diagnosis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne (other) |
| Locations | 1 site (Saint-Etienne) |
| Trial ID | NCT04053855 on ClinicalTrials.gov |
What this trial studies
This observational study aims to develop a reliable technique for detecting urinary exosomes in patients diagnosed with clear cell renal cell carcinoma. By utilizing electron microscopy and flow cytometry, the study will analyze urine samples to identify specific exosome markers associated with the cancer. The goal is to create a non-invasive biological test that could facilitate early diagnosis, potentially improving patient outcomes. The study will include patients undergoing nephrectomy for renal masses and will compare their urinary exosome profiles to those of control patients.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with a renal mass requiring surgical intervention, such as partial or total nephrectomy.
Not a fit: Patients with insufficient urine sample volume or those with urinary catheters may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a simple and non-invasive method for the early diagnosis of clear cell renal cell carcinoma.
How similar studies have performed: While the use of urinary exosomes for cancer detection is a promising area, this specific approach is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients: * All patients with renal mass requiring surgery (partial or total nephrectomy) * Social security affiliation * Signed informed consent Control : * Unscheduled nephrectomy * Social security affiliation * Signed informed consent Exclusion Criteria: * Insufficient volume of urine sample (\< 100 ml) * Patients with a urinary catheter * Patients under court-ordered guardianship or curators
Where this trial is running
Saint-Etienne
- Chu Saint-Etienne — Saint-Etienne, France (RECRUITING)
Study contacts
- Principal investigator: Nicolas MOTTET, MD PhD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Nicolas MOTTET, MD PhD
- Email: nicolas.mottet@chu-st-etienne.fr
- Phone: (0)477828331
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Clear Cell Renal Cell Carcinoma, Clear cell renal cell carcinoma, Urinary exosomes, Detection, Electron microscopy technique, Flow cytometry, RT-qPCR