Detecting severe sepsis in patients with brain hemorrhage
DetectIon of Severe Sepsis In PATients With Neurological haemorrhagE (The DISSIPATE Study)
National University Hospital, Singapore · NCT04624945
This study is testing if certain blood tests can help doctors spot severe sepsis early in patients with brain hemorrhages who are in intensive care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 21 Years to 100 Years |
| Sex | All |
| Sponsor | National University Hospital, Singapore (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Singapore) |
| Trial ID | NCT04624945 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify early predictors and validate laboratory parameters for managing sepsis in critically ill patients with neurological hemorrhage. It will enroll 150 subjects diagnosed with conditions like subarachnoid or intracerebral hemorrhage, who are expected to stay in the surgical intensive care unit for more than 48 hours. Blood samples will be collected daily over five days to analyze various hematological and inflammatory markers. The study will also gather clinical and demographic data to correlate these parameters with sepsis outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 and above with clinical or radiological evidence of neurological hemorrhage.
Not a fit: Patients who are under 21 years old, pregnant, or have conditions that preclude aggressive care may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of sepsis in patients with neurological injuries.
How similar studies have performed: Other studies have shown promise in identifying sepsis predictors in critically ill patients, but this specific approach in neurological hemorrhage is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults 21 years and above * Clinical/radiological suspicion or confirmation of neurological haemorrhage Exclusion Criteria: * Age below 21 years * Prisoners * Known pregnancy * Do-not-attempt resuscitation status * Requirement for immediate surgery * Active chemotherapy/neutropenia (Neutrophil count \<1.0 x 109/L) * Immuno-compromised * Haematological malignancy * Treating physician deems aggressive care unsuitable * Unable to provide informed consent or comply with study requirements
Where this trial is running
Singapore
- National University Hospital, Singapore — Singapore, Singapore (RECRUITING)
Study contacts
- Principal investigator: Will NH Loh, MBBS — National University Hospital, Singapore
- Study coordinator: Will NH Loh, MBBS
- Email: Will.Loh@nus.edu.sg
- Phone: 6772 4208
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sepsis, Hemorrhage Brain, Severe sepsis in patients with neurological haemorrhage