Detecting pancreatic cancer early using imaging and blood tests

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to find effective methods for early detection of pancreatic ductal adenocarcinoma (PDAC) in patients with high-risk pancreatic cystic neoplasms. Researchers will utilize a combination of advanced imaging techniques, including ImmunoPET scans and hyperpolarized MRI, alongside blood-based biomarkers to identify signs of PDAC. The goal is to develop a non-invasive approach to detect cancer early, potentially avoiding the need for surgical intervention. Participants will undergo these imaging tests and blood assays to evaluate their effectiveness in early detection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women aged \>18 years
* Pancreatic cystic neoplasm deemed to be high risk and requiring surgical resection
* Able to provide informed consent

Exclusion Criteria:

* Pathologic evidence of pancreatic cancer
* Pregnant or breast-feeding patients
* Refusal or inability to tolerate scan (eg anxiety or claustrophobia)
* Inability to lay flat or meet the standard requirements of traditional MRI
* Hepatic function from assays obtained within 6 weeks prior to the study enrollment. For each patient, the upper limit of normal (ULN) value for a particular assay will be defined by the normal reference values of the laboratory that performed the assay

  1. Bilirubin \> 1.5 x ULN
  2. AST/ALT \> 2.5 x ULN
  3. Albumin \< 3 g/dL
  4. GGT \> 2.5 x ULN if Alkaline Phosphatase \> 2.5 x ULN
* Renal function with Creatinine \> 1.5 x ULN or creatinine clearance \< 60 mL/min, from assays obtained within 6 weeks prior to study enrollment
* Cardiac: congestive heart failure with New York Heart Association (NYHA) status ≥2, poorly controlled hypertension, a history of clinically significant EKG abnormalities, or myocardial infarction within 6 months of study enrollment.

Where it's running

• Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
  Basking Ridge, New Jersey, United States Recruiting
• Memorial Sloan Kettering Monmouth (Limited protocol activities)
  Middletown, New Jersey, United States Recruiting
• Memorial Sloan Kettering Bergen (Limited Protocol Activities)
  Montvale, New Jersey, United States Recruiting
• Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity)
  Commack, New York, United States Recruiting
• Memorial Sloan Kettering Westchester (Limited Protocol Activities)
  Harrison, New York, United States Recruiting
• Memorial Sloan Kettering Cancer Center (All protocol activites)
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Kevin Soares, MD — Memorial Sloan Kettering Cancer Center
• Study coordinator: Kevin Soares, MD
• Email: soaresk@mskcc.org
• Phone: 212-639-3195

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.