Detecting fast brain signals to improve epilepsy treatment
Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
This study is testing new tiny electrodes to see if they can help find the source of seizures in people with hard-to-treat epilepsy, making it easier to plan better treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Sex | All |
| Sponsor | McGill University Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Trial ID | NCT05254730 on ClinicalTrials.gov |
What this trial studies
This study aims to enhance the identification of the epileptogenic zone in patients with refractory epilepsy by using novel intracranial electrodes equipped with micro-tetrodes to record fast ripples. The approach focuses on improving localization and reducing monitoring duration, particularly for patients who do not have enough seizures during the implantation period. Additionally, the study seeks to provide better surgical treatment options for patients whose previous assessments with macro-electrodes were inconclusive. The data collected will also contribute to a deeper understanding of the neuronal circuits involved in epilepsy.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with refractory epilepsy who are eligible for stereoelectroencephalography (sEEG) procedures.
Not a fit: Patients with severe psychiatric disorders, ongoing infections, or contraindications for MRI or intracerebral investigation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate identification of the epileptogenic zone, resulting in improved surgical outcomes for epilepsy patients.
How similar studies have performed: While this approach is innovative, similar studies using advanced electrode technology have shown promise in improving epilepsy treatment outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * inclusion criteria is determined based on the clinical diagnosis of the refractory epilepsy and the admissibility of the patient for the stereoelectroencephalography (sEEG) procedure Exclusion Criteria: * severe psychiatric disorders, * severe agitation during their crisis * contraindication for performing an MRI: claustrophobia, a cardiac or neural stimulator, ferromagnetic surgical clips, cochlear implants, intraocular metallic foreign body or in the nervous system, * contraindication to intracerebral investigation (macro-electrodes): ongoing infection, severe associated pathology (cardiac, pulmonary, renal, hepatic), pregnant or nursing women, * anti thrombotic ongoing treatment.
Where this trial is running
Montreal, Quebec
- McGill University — Montreal, Quebec, Canada (Recruiting)
Study contacts
- Study coordinator: Adrien Peyrache, PhD
- Email: adrien.peyrache@mcgill.ca
- Phone: 514-398-6780
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.