Detecting early heart failure in Greater Manchester

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate a novel multimodal risk calculator designed to identify individuals at risk of heart failure before its onset. The risk calculator incorporates key co-morbidities, circulating biomarkers, and cardiac magnetic resonance imaging (CMR) measurements to pinpoint those at highest risk. The pilot study will assess the uptake of this tool within primary care settings in Greater Manchester, focusing on recruiting participants from diverse and socioeconomically deprived backgrounds. Additionally, a preliminary analysis will evaluate the accuracy of the risk calculator and its potential cost-effectiveness in real-world applications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent
* Aged 50 and over
* Two or more of the following conditions: type 2 diabetes, chronic obstructive pulmonary disease, ischaemic heart disease, atrial fibrillation, hypertension, chronic kidney disease stage 3, body mass index ≥ 30 kg/m2

Exclusion Criteria:

* Established diagnosis of one or more of the following: heart failure, cardiomyopathy, moderate or severe valvular heart disease, congenital heart disease, heart transplant, idiopathic, heritable or drug-induced pulmonary arterial hypertension, any medical condition, which in the opinion of the Investigator, may place the patient at higher risk from his/her participation in the study, or is likely to prevent the patient from complying with the requirements of the study or completing the study.
* Contraindication to cardiovascular magnetic resonance (CMR) scanning, including pacemaker, defibrillator, intraocular metal, intracranial aneurysm clips, severe claustrophobia, estimated glomerular filtration rate \< 30 ml/min/1.73m2, previous severe allergic reaction or anaphylaxis to gadolinium-based contrast agent, pregnancy or breastfeeding.

Where it's running

• Manchester University NHS Foundation Trust
  Manchester, Greater Manchester, United Kingdom Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.