Detecting blood clots in patients with thromboembolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the feasibility of a novel device using Photoacoustic Flow Cytometry (PAFC) to detect circulating blood clots (CBCs) in patients diagnosed with thromboembolic disease. Current methods for detecting CBCs have poor sensitivity, especially when low numbers are present, leading to potential complications from undetected clots. By improving detection capabilities, this approach could enhance patient outcomes and reduce risks associated with thromboembolic conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Men and women, 18 years old and older.
* Evidence of current venous or arterial thromboembolic disease diagnosed by standard of care clinical, radiographic, or laboratory testing or acute ischemic stroke.
* Informed consent provided by the subject.

Exclusion Criteria

* Pulmonary embolus with a need for mechanical ventilation or other ventilator support (may be on oxygen delivered by nasal cannula or mask at an FiO2 of ≤ 0.40)
* Acute coronary syndrome (including unstable angina)
* Significant cardiac arrhythmia (may have atrial fibrillation controlled with medication)
* Intracardiac thrombus
* Any embolus or thrombus requiring vascular surgery or interventional radiology to attempt acute embolectomy or thrombectomy
* Sickle cell disease with vaso-occlusive crisis
* Sepsis or life-threatening infection
* Traumatic injury requiring hospitalization (within 30 days prior to enrollment)
* Pregnancy or breastfeeding
* Severe mental illness
* Other conditions deemed by the investigators to put the subject at greater risk

Where it's running

• Univerisity of Arkansas for Medical Sciences
  Little Rock, Arkansas, United States Recruiting

Study contacts

• Principal investigator: Sanjeeva Onteddu, MD — University of Arkansas
• Study coordinator: Sanjeeva Onteddu, MD
• Email: sronteddu@uams.edu
• Phone: 5016865135

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.