Detecting azole resistance in invasive aspergillosis patients using blood samples

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on immunocompromised patients suffering from invasive aspergillosis, a serious fungal infection. The researchers aim to optimize a PCR method to detect mutations associated with azole resistance in fungal DNA extracted directly from serum or plasma. By identifying these mutations quickly, the study seeks to enhance the diagnosis and treatment outcomes for patients infected with azole-resistant Aspergillus fumigatus. The study is particularly relevant given the high prevalence of azole resistance in the Netherlands.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years or older.
* Lung CT shows lesions that fulfil the EORTC/MSG radiological criteria of possible invasive fungal infection.
* A bronchoalveolar lavage is planned or has been performed \<48hrs earlier

Exclusion Criteria:

\- Patients unable or unwilling to provide consent

Where it's running

• Erasmus Medical Center (EMC)
  Rotterdam, South Holland, Netherlands Recruiting

Study contacts

• Study coordinator: Bart Rijnders, MD, PhD
• Email: b.rijnders@erasmusmc.nl
• Phone: +31107033510

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.