Detecting and treating air leaks from lungs during surgery
Official title: Defining Novel Strategies for the Diagnosis and Treatment of Intraoperative Air Leaks: An Ex-Vivo Human Lung Model Study
Run by Centre hospitalier de l'Université de Montréal (CHUM) · NCT05854654 · Data updated 2026-11-12
This study is testing a new way to find and fix air leaks during lung surgery using a special glue to help patients recover better and faster.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Centre hospitalier de l'Université de Montréal (CHUM) Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Status | Recruiting |
| Started | May 2, 2023 |
| Main results expected | April 1, 2027 |
| Study ends | April 1, 2027 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT05854654 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients undergoing lung transplant surgery and organ donors who are ineligible to donate lungs.
✕Probably not a fit
Healthy individuals will not benefit from this study as they do not meet the eligibility criteria.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on developing a method to detect, quantify, and treat air leaks that occur during lung surgery using a bio-adhesive. It aims to establish a standardized ex-vivo human lung model to optimize the detection and treatment process. The study will involve multiple procedures on lung models obtained from organ donors who are ineligible for lung donation. By analyzing tissue samples and images, the researchers hope to identify the most effective configurations for managing air leaks, ultimately reducing postoperative complications and hospital stays.
Why it matters
Potential benefit: If successful, this approach could significantly reduce complications and recovery time for patients undergoing lung surgery.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in managing surgical complications, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing lung transplant surgery * Organ donor ineligible to donate lungs Exclusion Criteria: * Healthy individuals
Where it's running
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Chum
Montreal, Quebec, Canada Recruiting
Study contacts
- Principal investigator: Moishe Liberman, MD — Chum
- Study coordinator: Moishe Liberman, MD
- Email: moishe.liberman@umontreal.ca
- Phone: 514-890-8000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using intraoperative ventilation to predict postoperative air leaks after thoracoscopic lobectomy or segmentectomy
This project will try using intraoperative ventilation during thoracoscopic lobectomy or segmentectomy to see if it can predict which patients will have postoperative air leaks.
-
Gas analyzer for chest drains to detect pleural air leaks
This study will test a small reusable gas analyzer that connects to chest drains to detect air leaks in adults undergoing thoracic surgery.
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Using aerosol glycerine to find air leaks in the lungs during surgery
This study is testing a new way to find air leaks in the lungs during surgery using a special mist to help doctors improve recovery for patients having lung operations.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.