Demineralized versus mineralized dentin grafts to preserve the upper back tooth ridge
Official title: Comparative Study Between Demineralized and Mineralized Allogeneic Dentin Grafts for Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial
Run by Kafrelsheikh University · NCT07242313 · Data updated 2026-11-12
We will test whether demineralized or mineralized donor dentin grafts better preserve bone after removing a single upper back tooth in healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | Kafrelsheikh University Academic / other |
| Locations | 1 site (Kafr ash Shaykh) |
| Status | Recruiting |
| Started | October 21, 2025 |
| Main results expected | August 1, 2026 |
| Study ends | August 31, 2026 |
| Registry record updated | November 24, 2025 |
| Trial ID | NCT07242313 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–60 who are medically healthy (ASA I), have a single non-restorable posterior maxillary tooth to be extracted, maintain good oral hygiene, and can attend follow-up visits are ideal candidates.
✕Probably not a fit
Smokers, pregnant or lactating women, people with uncontrolled systemic disease or bone metabolism disorders, and those needing larger simultaneous augmentation are unlikely to benefit from this specific protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial will assign 45 adults needing a single posterior maxillary extraction into three groups: spontaneous socket healing (control), demineralized allogeneic dentin graft, or mineralized allogeneic dentin graft. Clinicians will place the assigned treatment at the time of extraction and follow patients for six months. Cone beam CT (CBCT) will measure changes in ridge width, height, and bone density, and clinicians will collect biopsies at implant placement for histomorphometric analysis. Secondary outcomes include patient-reported pain, swelling, satisfaction, and keratinized tissue width.
Why it matters
Potential benefit: If successful, the results could help clinicians choose a graft material that better preserves bone and makes later implant placement more predictable.
How similar studies have gone: Small clinical reports and preclinical studies of demineralized dentin matrices have shown promising bone preservation, but randomized head-to-head comparisons of demineralized versus mineralized allogeneic dentin are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults aged 18 to 60 years. Medically healthy patients classified as ASA I. Presence of a single non-restorable tooth indicated for extraction in the posterior maxilla. Adequate oral hygiene, with plaque and bleeding indices both below 20%. Sufficient bone volume to allow socket preservation without requiring simultaneous augmentation. Patients willing to participate in the study and able to provide written informed consent. Ability to commit to follow-up visits for up to 6 months. Exclusion Criteria: Smokers or tobacco users of any form. Presence of uncontrolled systemic diseases (e.g., uncontrolled diabetes). Conditions affecting bone metabolism (e.g., osteoporosis, long-term corticosteroid therapy). Pregnant or lactating women. History of radiotherapy in the head and neck region. Active infection or suppuration at the extraction site. Immunocompromised patients or those on immunosuppressive therapy. Patients taking medications known to impair healing (e.g., bisphosphonates). Allergy or hypersensitivity to any study-related materials.
Where it's running
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Faculty of Dentistry, Kafrelsheikh University
Kafr ash Shaykh, Egypt Recruiting
Study contacts
- Principal investigator: Ahmed Elgendy, PhD — Faculty of Dentistry, Kafrelsheikh University
- Study coordinator: Ahmed Abdelaziz, BDS, MSc candidate
- Email: ahmed.mousa@den.kfs.edu.eg
- Phone: +201157315278
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Effect of four post-extraction socket approaches on preserving the ridge after tooth removal
This study tests four ways to care for an extraction socket to see which best preserves the jawbone and gum after tooth removal for future implants.
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Bone-preserving grafting with Biphasic Calcium Phosphate after tooth extraction
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This project tries to see if filling the socket after removing upper back teeth reduces the chance you'll need a sinus lift before getting a dental implant.
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Biotivity A/C Plus Membrane for Alveolar Ridge Preservation after Tooth Extraction
This study tests whether a human amnion chorion membrane helps healing and bone preservation better than a collagen membrane after extracting a back tooth and preparing the site for an implant.
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Evaluation of allogenic dentin grafts for preserving alveolar ridge after tooth extraction
This study is testing if using grafts from human teeth can help preserve the bone in the jaw after a tooth is taken out, making it easier for people to get dental implants later.
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This study is testing a new bone graft material to see if it can better preserve jawbone after tooth extractions compared to a standard option, helping people who need implants in the future.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.