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Clinical trial Recruiting at 1 site Interventional Ages 0 to 80

Delivering prenatal multiple micronutrient supplements to pregnant women in Uganda

Official title: Implementation of Multiple Micronutrient Supplementation (MMS) for Pregnant Women in Uganda

Run by Johns Hopkins Bloomberg School of Public Health · NCT06835738 · Data updated 2026-11-12

This project will test different MMS bottle sizes and delivery supports among pregnant women in Uganda to see which approach helps them take the supplements more regularly and attend antenatal care.

More Nutrient Deficiency trials

Quick facts

Study typeInterventional
Ages0 Years to 80 Years
SexAll
Enrollment4077 (estimated)
SponsorJohns Hopkins Bloomberg School of Public Health
Academic / other
Locations1 site (Lyantonde)
StatusRecruiting
StartedJune 18, 2025
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedSeptember 24, 2026
Trial IDNCT06835738 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal participants are pregnant women attending their first ANC visit at participating public or private-not-for-profit facilities in the selected districts, enrolled at ≤24 weeks gestation and willing to take MMS, with a separate single-contact sample including women ≤8 weeks postpartum who received MMS ≥3 months earlier.

Probably not a fit

Patients with pre-existing hematological disorders such as sickle cell disease, thalassemia, or hemochromatosis, those planning to relocate outside the study districts, or women who do not attend ANC at participating facilities are unlikely to benefit from this implementation intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a three-arm quasi-experimental implementation study using mixed methods across eight districts in the South Central, Acholi, and Karamoja regions of Uganda. The study compares dispensing MMS in 30-, 90-, and 180-count bottles alongside a contextualized social behavior change communication plan, capacity strengthening, supply chain support, and monitoring to measure acceptability, feasibility, fidelity, coverage, sustainability, adherence, ANC attendance, and cost impact. Quantitative measures will track adherence, ANC visit patterns, coverage, and budget impact while qualitative interviews with decision makers, providers, pregnant women, and community members will explore implementation experiences. MMS will be supplied to public and private not-for-profit facilities in the selected districts and data collected from women enrolled early in pregnancy and from a separate sample of women who received MMS previously.

Why it matters

Potential benefit: If successful, the approach could increase supplement adherence and ANC attendance, improve maternal micronutrient status and birth outcomes, and support scaling MMS within routine ANC services in Uganda.

How similar studies have gone: Clinical trials have shown MMS can improve maternal micronutrient status and some birth outcomes compared with iron–folic acid, but large-scale implementation within national ANC systems like Uganda's is less well tested.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria for Pregnant women- Enrolled for follow-up throughout pregnancy (sample 1)

* ≤24 weeks of amenorrhea/gestation as verified by health professionals
* Attending first ANC visit at government or PNFP health facilities.
* Accepted to take MMS at first ANC visit

Exclusion Criteria for Pregnant women- Enrolled for follow-up throughout pregnancy (sample 1)

* Pregnant women with pre-existing hematological conditions such as sickle cell anemia, thalassemia, hemochromatosis.
* Pregnant women planning to relocate outside the study district during the study period.

Inclusion Criteria for Pregnant women / Women that have recently delivered (single contact) (sample 2)

* Currently pregnant woman or a woman who is not more than 8 weeks postpartum.
* Received MMS at an ANC visit at least 3 months ago or more.
* Attended at least any 2 monthly ANC visits.
* Attending/attended ANC at government or private-not-for-profit health facility.

Exclusion Criteria for Pregnant women / Women that have recently delivered (single contact) (sample 2)

* Enrolled in study population 1.
* Women who are more than 8 weeks postpartum.

Inclusion Criteria for ANC providers having ANC health education/counseling with pregnant woman(en) observed (sample 3)

• Healthcare providers that are currently providing ANC health education (group) or ANC individual counseling at government or PNFP health facilities.

Exclusion Criteria for ANC providers having ANC health education/counseling with pregnant woman(en) observed (sample 3) • Healthcare providers that are currently providing ANC health education (group) or ANC individual counseling to a woman(en) that have not provided written informed consent to have the ANC session observed.

Inclusion Criteria for Influential family members (male partners \& mothers/mothers-in law) (sample 4)

* Spouse or partner of a pregnant woman or woman with a child less than 8 weeks old who is receiving/ has received ANC services in one of the 8 study districts.
* Mother or mother-in-law of a pregnant woman or woman with a child less than 8 weeks old who is receiving/ has received ANC services in one of the 8 study districts.

Exclusion Criteria for Influential family members (male partners \& mothers/mothers-in law) (sample 4) • None

Inclusion Criteria for Healthcare Providers- including facility in-charge, ANC providers, Health Assistants, staff in-charge of records, and stores manager (sample 5)

* Health workers who provide ANC services (e.g., midwives/nurse, medical/ clinical officers, health assistants, and nutrition focal person) at government or private-not-for-profit facilities in one of the 8 study districts.
* Health facility staff (e.g., Facility In-charge, Maternity In-charge, Pharmacy/Stores In-charge) at government or private-not-for-profit facilities in one of the 8 study districts.

Exclusion Criteria for Healthcare Providers- including facility in-charge, ANC providers, Health Assistants, staff in-charge of records, and stores manager (sample 5)

• None

Inclusion Criteria for Community Health Workers (VHTs) and Mentor Mothers (sample 6) • Voluntary Health Team (VHT), Mentor Mothers, or Para-socials attached to at least one of the study facilities.

Exclusion Criteria for Community Health Workers (VHTs) and Mentor Mothers (sample 6) • None

Inclusion Criteria for National, regional, and district-level stakeholders (sample 7)

* National, regional, or district-level decision-makers working in nutrition, maternal, newborn and child health, district health educator or pharmaceutical roles associated with the antenatal care system in Uganda.
* Implementing partners involved in direct implementation of MMS within the 8 study districts

Exclusion Criteria for National, regional, and district-level stakeholders (sample 7)

• None

Inclusion Criteria for Pregnant women - interviewed during post-intervention Household Coverage Survey (sample 8)

* Woman who has been pregnant or delivered within the study period.
* Household is within one of the 4 selected districts.

Exclusion Criteria for Pregnant women - interviewed during post-intervention Household Coverage Survey (sample 8)

• Women who moved to the district after delivery.

Where it's running

  • Lyantonde GH
    Lyantonde, Uganda     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.