Delgocitinib, lidocaine, or both for itch relief in healthy adults
Official title: The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch Sensitivity in Healthy Volunteers
Run by Aalborg University · NCT07203274 · Data updated 2026-11-12
This study tests whether delgocitinib, lidocaine, or their combination can reduce experimentally induced itching in healthy adults aged 18-60.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Aalborg University Academic / other |
| Drugs / interventions | delgocitinib |
| Locations | 1 site (Gistrup) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | November 9, 2026 |
| Trial ID | NCT07203274 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18-60 who understand English and have no pregnancy, lactation, or contraindicated conditions.
✕Probably not a fit
Individuals with skin conditions, neurological issues, or medications that affect itching may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study examines the effects of delgocitinib cream, lidocaine cream, their combination, a vehicle placebo, and histamine challenge on itching in healthy volunteers. Participants receive one of the topical treatments and are exposed to an itchy stimulus to assess itch relief. The study excludes individuals with recent skin conditions, neurological or systemic disorders, or medications that could alter responses. Outcomes focus on itch intensity and safety following topical application. The trial is conducted at Aalborg University in Denmark and targets short-term, controlled itch responses.
Why it matters
Potential benefit: If successful, participants may experience faster or greater itch relief from the tested formulations.
How similar studies have gone: Previous data suggest anti-itch and pain-relief effects for similar topical agents, but the combination approach in this exact design is less established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy men and women * 18-60 years * Speak and understand English Exclusion Criteria: * Pregnancy or lactation * Drug addiction defined as any use of cannabis, opioids, or other drugs that may cause addiction. * Previous or current history of neurological, dermatological (e.g., AD, psoriasis, etc.), immunological, musculoskeletal, cardiac disorder or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.) * Moles, wounds, scars, or tattoos in the area to be treated or tested * Current use of medications that may affect the trial such as antihistamines and painkillers * use of antihistamines should be discontinued 72 hours before the experiment and all topical agents and emollients should be discontinued 24 hours before the experiment). * Use of systemic and topical corticosteroids * Previous traumatic experience of an electrical accident * Application of moisturizing lotion of the volar site of the forearms (24 hours before study start) * Skin diseases * Consumption of alcohol or painkillers 24 hours before the study days and between these * Acute or chronic pain and itch * Known allergy/intolerance to lidocaine/phenytoin/mepyramine * Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies) * Lack of ability to cooperate
Where it's running
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Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark
Gistrup, Denmark Recruiting
Study contacts
- Study coordinator: Silvia Lo Vecchio
- Email: slv@hst.aau.dk
- Phone: +4521397785
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.