Deciding which add-on treatments and IV furosemide doses to use for people hospitalized with heart failure
Official title: Preparatory Work for a Multi-arm, Multi-stage Trial of Adjunctive Treatments in Patients Hospitalised With Heart Failure (Pre-MAMMOTH-HF)
Run by Hull University Teaching Hospitals NHS Trust · NCT07281040 · Data updated 2026-11-12
This project will gather clinician and patient input to decide which add-on treatments, doses, and outcomes to test for people recently hospitalized with heart failure.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | Hull University Teaching Hospitals NHS Trust Government |
| Locations | 1 site (Hull, Yorkshire) |
| Status | Recruiting |
| Started | July 2, 2025 |
| Main results expected | October 1, 2026 |
| Study ends | October 1, 2026 |
| Registry record updated | December 15, 2025 |
| Trial ID | NCT07281040 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People who were hospitalized with heart failure within the past six months (or their carers) and who can take part in online group discussions in English.
✕Probably not a fit
Patients who were not recently hospitalized, cannot join online English discussions, or need translation/support to participate are unlikely to directly benefit from this preparatory project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational preparatory project combines an online clinician survey, a modified-Delphi expert panel, and a patient-and-carer advisory group to define the design of a future randomized trial. Clinicians (doctors, nurses, pharmacists) at sites across the UK will complete a Qualtrics survey about acceptability of adjuncts, willingness to randomize, and realistic recruitment capacity. An expert panel of ~20–25 clinicians and allied health professionals will use the evidence and a modified Delphi process to recommend adjunct selection, comparator IV furosemide doses, and primary/secondary outcomes. A patient-and-carer panel of people recently hospitalized for heart failure will advise on meaningful endpoints and acceptability of interventions.
Why it matters
Potential benefit: If successful, this work could enable a well-designed randomized trial that identifies safer or more effective add-on diuretic strategies to speed recovery and reduce rehospitalizations after heart failure hospitalization.
How similar studies have gone: Delphi panels and clinician/patient surveys are commonly used to shape trial design and endpoints and have improved relevance in other cardiovascular research, though specific adjunctive strategies for acute heart failure remain relatively under-tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Recent hospitalisation with heart failure (\<6 months) or carer for a person with a recent hospitalisation with heart failure. 2. Able to participate in online group discussions in English Exclusion Criteria: 1\. Unable to participate in online group discussions in English
Where it's running
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Cardiology
Hull, Yorkshire, United Kingdom Recruiting
Study contacts
- Principal investigator: Joe Cuthbert, MBBS MD — Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Cottingham Road, Kingston-Upon-Hull, HU6 7RX
- Study coordinator: Joe Cuthbert, MBBS MD
- Email: joe.cuthbert@hyms.ac.uk
- Phone: +441482 875875
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.