Database investigation of endovascular therapy for acute ischemic stroke
Investigation and Study on the Status of Endovascular Therapy in Acute Ischemic Stroke
Second Affiliated Hospital, School of Medicine, Zhejiang University · NCT03909438
This study is trying to see how well endovascular therapy works for people with acute ischemic stroke by collecting information from over 1,000 patients in China.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University (other) |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT03909438 on ClinicalTrials.gov |
What this trial studies
This observational study aims to create a comprehensive database for patients with acute ischemic stroke who undergo endovascular therapy. It will analyze the effectiveness, safety, and cost-effectiveness of this treatment approach in China. The study will enroll at least 1,000 patients across 70 centers, collecting data on various clinical factors and outcomes. The primary endpoints include the proportion of patients with good prognosis after 90 days and the incidence of intracranial hemorrhage transformation within 24 hours.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with clinical signs of acute ischemic stroke and specific imaging criteria.
Not a fit: Patients with large cerebral infarctions, severe glucose abnormalities, or other serious illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding and application of endovascular therapy for acute ischemic stroke, potentially improving patient outcomes.
How similar studies have performed: Previous studies have shown promising results with endovascular therapy for acute ischemic stroke, indicating a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Clinical signs and symptoms consistent with the diagnosis of an acute ischemic stroke 2. Age ≥18 years 3. NIHSS ≥ 6 4. ICA or MCA-M1 or MCA-M2 occlusion as evidenced by MRA or 4D-CTA 5. Ethrombectomy can be initiated (femoral puncture) within 6 hours after onset or between 6 and 24 hours after time last know well if conform to the imaging inclusion criteria: Target Mismatch Profile on CT perfusion or MR perfusion: ischemic core volume is ≤ 70 ml, mismatch ratio is ≥ 1.8, penumbra volume is ≥ 15 ml. Exclusion Criteria: 1. Large area cerebral infarction of anterior circulation on early CT image (more than 1/3 of cerebral hemisphere) 2. Blood glucose \<2.7mmol/L or \>22.2mmol/L 3. Other serious, advanced, or terminal illness (investigator judgment) or life expectancy is less than 90 days 4. Pregnant
Where this trial is running
Hangzhou, Zhejiang
- Second Affiliated Hospital, School of Medicine, Zhejiang University — Hangzhou, Zhejiang, China (RECRUITING)
Study contacts
- Study coordinator: Min Lou, Ph.D
- Email: loumingxc@vip.sina.com
- Phone: 13958007213
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke, Endovascular Therapy