Daily pistachios for people taking GLP-1 weight-loss medicines

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults who have been taking GLP‑1 receptor agonists such as semaglutide or tirzepatide for at least three months will add pistachios to their meals for 12 weeks while remaining on their medication. Researchers will measure appetite and eating enjoyment, track diet quality and weight-related outcomes, and perform DEXA scans to assess body composition changes. Blood markers and patient-reported tiredness/energy will also be collected to look for metabolic or wellbeing effects. The protocol focuses on a defined population already using GLP‑1 therapy to see if a simple dietary change adds measurable benefits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals with a BMI ≥30 kg/m2 or with a BMI ≥27 kg/m2 with at least one weight-related comorbidity who have been continuously using semaglutide or tirzepatide for three months for a clinical indication and remain on the therapy at the time of enrollment

Exclusion Criteria:

* No use or contraindication to use of a GLP-1 RA
* Known allergy to nuts
* Pregnant or breastfeeding
* Incarcerated

Where it's running

• University Hospitals Cleveland Medical Center
  Clevland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Ian Neeland, MD — University Hospitals Cleveland Medical Center
• Study coordinator: Ian Neeland, MD
• Email: Ian.Neeland@UHhospitals.org
• Phone: 216-844-5965

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.