Daily mangos for gut and cardiometabolic health in Hispanic/Latino teens
The Influence of Mango-Derived Intestinal Microbial Metabolites on Gut Permeability, Inflammation, and Cardiometabolic Health Markers in Hispanic/Latino Adolescents
This project will see if eating a daily serving of Ataulfo mango for four weeks instead of calorie-dense snacks improves gut microbes, inflammation, and cardiometabolic markers in Hispanic/Latino adolescents with overweight or obesity.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 12 Years to 19 Years |
| Sex | All |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Davis, California) |
| Trial ID | NCT07125001 on ClinicalTrials.gov |
What this trial studies
This randomized, controlled 2-arm crossover trial will enroll 25 Hispanic/Latino adolescents aged 12–19 with BMI at or above the 85th percentile. Participants will be randomized to consume 3/4 cup of Ataulfo mango daily for four weeks or continue their habitual diet, followed by a four-week washout and crossover to the alternate condition. Outcomes include changes in gut microbiome composition and microbial metabolites, markers of inflammation, and cardiometabolic and vascular function measured before and after each intervention period. Study procedures include standardized mango portioning, dietary compliance monitored by daily smartphone photos, and physiological and laboratory assessments at the research center in Davis, California.
Who should consider this trial
Good fit: Ideal candidates are self-identified Hispanic/Latino adolescents aged 12–19 with BMI at or above the 85th percentile who are willing to eat the test mango portions daily and use a smartphone to document intake.
Not a fit: Those unlikely to benefit include adolescents with BMI below the 85th percentile, people with mango or other food allergies, those on prescription medications (except inhalers), or those already in a high-intensity daily exercise program.
Why it matters
Potential benefit: If successful, the intervention could offer a simple, culturally acceptable snack substitution that improves gut health, lowers inflammation, and modestly improves cardiometabolic risk markers in at-risk adolescents.
How similar studies have performed: Prior animal studies and small human studies of fruit, fiber, and mango components suggest potential microbiome and metabolic benefits, but randomized crossover trials in adolescents—especially in Hispanic/Latino populations—are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \- Male or Female 12-19 years old * BMI ≥ 85th percentile (https://www.bcm.edu/bodycomplab/BMIapp/BMI-calculator-kids.html) * Self-reported Hispanic/Latino * Subject is willing and able to comply with the study protocols * Subject is willing to consume the test products * Female-specific criteria: if menstruating, eumenorrheic (regular monthly menstrual cycles of 25-30-days in length) * Access to a smartphone or tablet at least 1x / day and willing to take pictures associated with the products to be consumed in the study Exclusion Criteria: * \- Reported food allergies. * Currently taking prescription drugs, with the exception of asthma inhalers, which are allowed * BMI \<85th percentile (https://www.bcm.edu/bodycomplab/BMIapp/BMI-calculator-kids.html) * Current participation in a moderate or high-intensity daily exercise routine * Self-reported disease, serious illness, or who are currently under acute medical care. * Currently taking prescription drugs. * Any supplement use, including multi-vitamin/ mineral, herbal, plant or botanical, fish oil, and oil supplements, and not willing to discontinue before starting the study. * Vegetarian or vegan diet * Self-reported malabsorption or gastrointestinal issues * Fruit and vegetable intake exceeding daily recommendations of 5 servings * Smoking (vaping, conventional nicotine-containing products or marijuana) * Current enrollee in a clinical research study
Where this trial is running
Davis, California
- Academic Surge; Ragle Human Nutrition Research Center — Davis, California, United States (Recruiting)
Study contacts
- Principal investigator: Roberta R Holt, PhD — University of California, Davis
- Study coordinator: Roberta R Holt, PhD
- Email: rrholt@ucdavis.edu
- Phone: 15304005952
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.