Daily lemongrass tablets with HIIT to try to improve aerobic fitness in middle-aged men

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled, parallel-group trial in men aged 40–60 comparing daily lemongrass extract tablets to placebo over a 6-week supervised HIIT program. Participants attend about 23 laboratory visits for familiarisation, baseline and post-intervention fitness testing (including graded cycle tests to near exhaustion with gas analysis and lactate sampling), repeated blood draws, and sexual wellness measures. The protocol includes daily supplement dosing during the training period and monitoring of heart rate, exercise performance, and blood biomarkers. Outcomes will compare changes in aerobic capacity, exercise efficiency, and self-reported sexual wellness between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 40 and ≤ 60 years.
* Body Mass Index (BMI) ≥ 19 and ≤ 35 kg/m2.
* Willingness and ability to comply with the protocol in the opinion of the Investigator.
* Judged by the Investigator to be in good health as assessed by a health screening questionnaire.
* Currently identifies as the same biological sex as at birth.
* Currently deemed to be between a physical activity status of sedentaryy to moderately trained (Meet World Health Organization minimum activity guidelines: Adults aged 18-64 years old completing at least 150 to 300 min moderate-intensity activity or 75-150 min of vigorous-intensity activity a week, plus muscle-strengthening activities 2 or more days a week).
* Have a blood pressure \< 140/90 mmHg.

Exclusion Criteria:

* A history of heart disease.
* Any disease that might interfere with the absorption of nutrients (e.g. Chron's disease, celiac disease).
* Recent musculoskeletal or soft tissue injury (within the last 3 months).
* The habitual use of medication that is antihypertensive or antidiabetic medication or might inhibit the ability to complete the study participation.
* Alcohol Intake of greater than 21 units per week.
* A change in bodyweight of more than 3kg within the month preceding the study.
* Currently following a weight-loss or weight-gain programme.
* Any known bleeding disorder or reaction to withdrawal of blood samples

Where it's running

• Northumbria University
  Newcastle upon Tyne, United Kingdom Recruiting

Study contacts

• Principal investigator: Glyn Howatson — Northumbria Univeristy
• Study coordinator: Emma Squires, Dr
• Email: emma2.squires@northumbria.ac.uk
• Phone: 07585775838

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.