Daily avocado to slow cellular aging in breast cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial will assign eligible breast cancer survivors to eat one avocado per day or continue their habitual diet (fewer than two avocados per week) for the intervention period. The primary outcome is change in leukocyte telomere length, with secondary outcomes including telomerase activity, markers of inflammation and oxidative stress, cardiovascular risk markers, anthropometrics, mood, quality of life, fatigue, and diet quality. Participants are women aged 40–65 who finished radiotherapy and/or chemotherapy 6 months to 10 years prior and currently consume fewer than two avocados per week. The trial is run at the Unit for Public Health and Nutritional Epidemiology, Universitat Rovira i Virgili in Reus, Tarragona.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women diagnosed with primary breast cancer in stages I, II or III;
* 40-65 years old at screening;
* Cancer treatment (radiotherapy and chemotherapy) completed ≥ 6 months but not more than 10 years at the time of recruitment;
* Currently consuming less than 2 avocados per week;
* Signed the informed consent letter.

Exclusion Criteria:

* Metastasis;
* Ductal carcinoma or lobular carcinoma in situ;
* Breast cancer recurrence;
* Cancer diagnosis other than breast cancer or non-melanoma skin cancer;
* Body mass index ≥40kg/m2;
* Currently pregnant or breastfeeding, or planning pregnancy in the following 6 months;
* Allergy to latex;
* Unwilling to consume avocado;
* Immunodeficiency or HIV-positive status;
* Alcohol abuse (\>50g/day);
* Unstable use of plant sterols, mineral supplements, use of fibre supplements, fish oil, or antioxidants in the 4 weeks prior to enrolment, or plans to change this during the study;
* Currently participating in any other randomized controlled trial;
* Difficulty or impossibility of an adequate follow-up;
* Inability or unwillingness to give written informed consent or to communicate with study personnel, or illiteracy;
* Patients with an acute infection or inflammation (e.g., pneumonia) will be allowed to participate in the study 3 months after recovery.

Where it's running

• Unit for Public Health and Nutritional Epidemiology, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili
  Reus, Tarragona, Spain Recruiting

Study contacts

• Study coordinator: Nerea Becerra Tomás, PhD
• Email: nerea.becerra@urv.cat
• Phone: +34977759334

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.