D-lactate test in spinal fluid for suspected ventriculostomy-related meningitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center study in the neurosurgical ICU at Toulouse University Hospital collects an extra cerebrospinal fluid (CSF) sample when clinicians perform routine sampling for suspected ventriculostomy-related nosocomial meningitis. Samples are frozen at -80°C and will undergo serial assays for D‑lactate, procalcitonin (PCT), and pro-inflammatory cytokines (IL-1, IL-6, IL-8, TNFα). If the initial CSF does not meet diagnostic criteria, a second sample is taken 48–96 hours later; final clinical classification of meningitis versus no meningitis is made retrospectively by two neurosurgical intensivists using the medical record. Participants are followed through an end-of-participation visit at four weeks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ⩾ 18 years.
* Patient with an external ventriculostomy implanted at the Toulouse University Hospital.
* Patient suspected of nosocomial meningitis due to a febrile syndrome (in the absence of any other identified infectious site), headache, nausea, lethargy, change in neurological status, meningeal syndrome, epileptic event and cutaneous or subcutaneous inflammation at the ventriculostomy site of insertion.
* Patient having expressed oral consent, after free and informed information.
* Patient affiliated to a social security scheme.

Exclusion Criteria:

* Diagnosis of community meningitis.
* Proven or suspected meningitis and/or ventriculitis during the previous month.
* Diagnosis of nosocomial meningitis made in another medical centre prior to admission.
* Short bowel syndrome.
* Acute mesenteric ischaemia.
* End-stage renal failure (GFR \< 15 ml/min/m2).
* Peritoneal dialysis.
* Patient participating in another research protocol with an exclusion period still in progress.
* Pregnant or breastfeeding woman.
* Patient under guardianship or trusteeship, persons placed under the protection of justice

Where it's running

• Toulouse Hospital
  Toulouse, France Recruiting

Study contacts

• Study coordinator: Lucie LELIEVRE, Md
• Email: lelievre.l@chu-toulouse.fr
• Phone: 0561777198

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.