D-2570 treatment for moderate to severe plaque psoriasis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled Phase 3 multicenter trial planning to enroll about 390 subjects with moderate to severe plaque psoriasis. Eligible participants must have BSA ≥10%, PASI ≥12, and PGA ≥3 and have disease judged suitable for systemic therapy and stable for at least six months. Participants are randomly assigned to receive either D-2570 or placebo and are followed for predefined efficacy and safety outcomes. Standard laboratory tests and regular clinic visits are used to monitor response and adverse events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Subject voluntarily takes part in the study after being fully informed,signs a written ICF, and agrees to follow procedures specified in the study protocol;
2. Plaque psoriasis assessed by the investigator as suitable for systemic treatment and stable (defined as stable as no significant outbreak of morphological change or disease activity assessed by the investigator) for at least 6 months prior to signing informed consent;
3. During the screening period and before taking the investigational drug for the first time, psoriatic surface area (BSA) ≥10%, PGA score ≥ 3, PASI score ≥ 12;
4. Hematology, Blood chemistry and Urinalysis examination were basically normal.

Exclusion Criteria:

1. Erythrodermic psoriasis, pustular psoriasis, guttate psoriasis, reverse psoriasis, drug-induced psoriasis;
2. Have other skin lesions that affect the evaluation of treatment outcomes, such as eczema;
3. History of herpes zoster/herpes simplex, or presence of herpes zoster/herpes simplex infection during the screening period;
4. Have a history of tuberculosis, or active tuberculosis, or latent tuberculosis, or suspected clinical manifestations of tuberculosis infection;
5. Other conditions that the investigator considers inappropriate for participation in the study.

Where it's running

• Peking University People's Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Jianzhong Zhang — Study Official is required by the WHO and ICMJE.
• Study coordinator: Nan Tang
• Email: nan.tang@inventisbio.com
• Phone: 021-50663661

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• D-2570 oral treatment for adults with moderate to severe plaque psoriasis

  This trial tests whether the oral medicine D-2570 helps adults with moderate to severe plaque psoriasis compared with placebo and an approved oral drug.

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• Long-term zasocitinib treatment for children and teenagers with plaque psoriasis

  This long-term study will see if the medicine zasocitinib is safe and helps children and teenagers (ages 4 to under 18) with moderate-to-severe plaque psoriasis.

  Recruiting at 37 sites Phase 3 Takeda · Chula Vista, California and 38 other locations · NCT07250802

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.