CXCR4-targeted PET/CT to find the source of Cushing's syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational effort at Peking Union Medical College Hospital will image patients with suspected or confirmed Cushing's syndrome using 68Ga‑Pentixafor (CXCR4) PET/CT. Imaging results will be compared with conventional modalities and with 68Ga‑DOTATATE PET/CT when available to aid differential diagnosis between ACTH-dependent and ACTH-independent forms and to localize primary lesions. Participants will undergo PET/CT imaging alongside routine biochemical and clinical evaluation, with image findings correlated to clinical reference standards. Performance metrics such as sensitivity, specificity, and localization rates will be reported.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical suspicion or confirmed diagnosis of Cushing's syndrome, based on clinical features (e.g., central obesity, moon face, muscle weakness) and/or abnormal cortisol-related biochemical tests.
* Able and willing to undergo PET/CT imaging with both 68Ga-Pentixafor and, when applicable, 68Ga-DOTATATE.
* Willing to provide informed consent for participation in the study.

Exclusion Criteria:

* Prior administration of therapeutic or investigational radiopharmaceuticals within 5 physical half-lives before study imaging.

Pregnancy or breastfeeding.

* History of allergic reaction to gallium-based tracers or related compounds.
* Clinically unstable condition or severe organ dysfunction that, in the investigator's opinion, would interfere with PET/CT imaging or study participation.
* Inability to complete both 68Ga-Pentixafor and, when applicable, 68Ga-DOTATATE PET/CT imaging due to clinical or logistical reasons.

Where it's running

• Peking Union Medical College Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Zhaohui Zhu, MD
• Email: 13611093752@163.com
• Phone: 86-13611093752

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.