Customized donor bone block versus your own bone for rebuilding the jaw ridge

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with 1–4 missing teeth and an insufficient alveolar ridge (<5 mm width) receive either a customized allogeneic bone block or an autogenous (patient's own) bone block with standard graft and flap surgery. Outcomes are measured using three-dimensional clinical and radiological imaging, safety and biocompatibility monitoring, complication tracking, and patient-reported outcome measures. Implant condition is followed one year after implantation and during annual follow-ups for up to five years. The procedures and follow-up visits are performed at the Department of Dental Medicine and Oral Health, Medical University of Graz.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA

* 1-4 missing teeth that need to be replaced with dental implants
* Bone ridge width insufficient for dental implant placement; \<5 mm of width as measured in a cone beam computed tomography at the ideal prosthetic position
* Medically healthy with no known allergies to antibiotics
* Non-smoker or light smoker (\< 10) or previous smoker who had quit for 5 years or more
* Periodontal health, as confirmed by clinical examination (Full mouth bleeding score and full mouth plaque score \< 25%) and at least one neighboring natural tooth to the defect site(s)
* Age of 18 or above

EXCLUSION CRITERIA

* All contraindications against implant treatment or augmentative procedures (e.g., advanced systemic diseases, corticosteroid medication, immunodeficiency, pregnancy, intention to become pregnant, breastfeeding, lack of safe contraception)
* Treatments or diseases that may have an effect on bone turnover or the bone itself or non-mineralized tissue metabolism (e.g., bisphosphonates or local radiotherapy, skeletal immaturity)
* Pathological fractures such as those observed in (but not limited to) Paget's disease or in metastatic bone diseases
* Any active malignancy or patient undergoing treatment for a malignancy Study protocol: IndiALLO Version 4/19.03.2025 Page 9 von 32
* Contraindications to the class of drugs under study, e.g., known hypersensitivity or allergy to class of drugs or the investigational product
* Persistent compartment syndrome or neurovascular residua of compartment syndrome

Where it's running

• Department of Dental Medicine and Oral Health, Division of Oral Surgery and Orthodontics, Medical University of Graz
  Graz, Styria, Austria Recruiting

Study contacts

• Study coordinator: Michael Payer, Assoz.Prof.
• Email: mi.payer@medunigraz.at
• Phone: +4331638580659

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Two bovine bone grafts in sinus lift with or without jaw marrow blood

  This study tests whether adding a small amount of jawbone marrow blood to two bovine bone grafts helps create more new bone and height in sinus lift surgery for adults needing implants.

  Recruiting Universidad del Desarrollo · Santiago, Santiago Metropolitan · NCT07904065

• Melatonin Gel in Immediate Molar Implants in the Back of the jaw

  In this small study, researchers test whether applying a 1% melatonin gel during immediate molar implant placement in the back of the lower jaw helps with healing and bone formation.

  Recruiting Future University in Egypt · Cairo · NCT07869030

• Bone marrow cells plus Bio-Oss graft for repairing severe jawbone defects

  This study tests whether using a patient’s own bone marrow–derived mononuclear cells mixed with Bio-Oss graft can repair severe maxillofacial bone defects in adults aged 18-60.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07852806

• Porous zirconia shell to widen the jawbone before implants

  A small group of adults with a narrow lower back jaw will try a custom porous zirconia shell placed over bone grafts to see if it helps form good-quality new bone before placing dental implants.

  Recruiting October University for Modern Sciences and Arts · Giza, Giza Governorate · NCT07841158

• Immediate molar implants with customized healing abutments in different socket classes

  This study tests placing an implant right after extracting a back tooth and using a custom healing cap to shape the gum from day one, in people needing posterior implants.

  Recruiting Plovdiv Medical University · Plovdiv · NCT07801573

• Thermosensitive THBC + CGF for Bone Building After Wisdom Tooth Removal

  This real-world study tests whether a thermosensitive hydroxyethylchitosan with concentrated growth factor can help rebuild bone in the socket after removing a lower wisdom tooth.

  Recruiting Stomatological Hospital Affiliated with Fujian Medical University · Fuzhou, Fujian · NCT07779421

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.