Customized donor bone block versus your own bone for rebuilding the jaw ridge
Comparison of Customized Allogenic Versus Autogenous Bone Block Graft for Alveolar Ridge Augmentation
This study tests whether customized donor (allogeneic) bone blocks work as well as bone taken from your own body to rebuild the jaw ridge for adults who need dental implants.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 26 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of Graz Academic / other |
| Locations | 1 site (Graz, Styria) |
| Trial ID | NCT07419269 on ClinicalTrials.gov |
What this trial studies
Adults with 1–4 missing teeth and an insufficient alveolar ridge (<5 mm width) receive either a customized allogeneic bone block or an autogenous (patient's own) bone block with standard graft and flap surgery. Outcomes are measured using three-dimensional clinical and radiological imaging, safety and biocompatibility monitoring, complication tracking, and patient-reported outcome measures. Implant condition is followed one year after implantation and during annual follow-ups for up to five years. The procedures and follow-up visits are performed at the Department of Dental Medicine and Oral Health, Medical University of Graz.
Who should consider this trial
Good fit: Adults (18+) with 1–4 missing teeth needing implants, a jaw ridge width under 5 mm at the planned implant site, good periodontal health, medically healthy status, and who are non-smokers, light smokers (<10/day), or long-term ex-smokers are ideal candidates.
Not a fit: Patients with contraindications to implant or augmentative procedures (advanced systemic disease, immunodeficiency, corticosteroid use), conditions or treatments affecting bone turnover (e.g., bisphosphonates), heavy smokers, pregnant or breastfeeding individuals, or those lacking safe contraception are unlikely to benefit.
Why it matters
Potential benefit: If successful, patients could avoid harvesting their own bone while achieving comparable ridge reconstruction, reducing donor-site pain and recovery time.
How similar studies have performed: Prior clinical reports of allogeneic bone block use in ridge augmentation have shown promising results, but autogenous grafting remains the established clinical standard.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA * 1-4 missing teeth that need to be replaced with dental implants * Bone ridge width insufficient for dental implant placement; \<5 mm of width as measured in a cone beam computed tomography at the ideal prosthetic position * Medically healthy with no known allergies to antibiotics * Non-smoker or light smoker (\< 10) or previous smoker who had quit for 5 years or more * Periodontal health, as confirmed by clinical examination (Full mouth bleeding score and full mouth plaque score \< 25%) and at least one neighboring natural tooth to the defect site(s) * Age of 18 or above EXCLUSION CRITERIA * All contraindications against implant treatment or augmentative procedures (e.g., advanced systemic diseases, corticosteroid medication, immunodeficiency, pregnancy, intention to become pregnant, breastfeeding, lack of safe contraception) * Treatments or diseases that may have an effect on bone turnover or the bone itself or non-mineralized tissue metabolism (e.g., bisphosphonates or local radiotherapy, skeletal immaturity) * Pathological fractures such as those observed in (but not limited to) Paget's disease or in metastatic bone diseases * Any active malignancy or patient undergoing treatment for a malignancy Study protocol: IndiALLO Version 4/19.03.2025 Page 9 von 32 * Contraindications to the class of drugs under study, e.g., known hypersensitivity or allergy to class of drugs or the investigational product * Persistent compartment syndrome or neurovascular residua of compartment syndrome
Where this trial is running
Graz, Styria
- Department of Dental Medicine and Oral Health, Division of Oral Surgery and Orthodontics, Medical University of Graz — Graz, Styria, Austria (Recruiting)
Study contacts
- Study coordinator: Michael Payer, Assoz.Prof.
- Email: mi.payer@medunigraz.at
- Phone: +4331638580659
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.