Curcumin nanogel versus 0.1% fluocinolone acetonide oral paste for atrophic-erosive oral lichen planus

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, controlled comparison of curcumin formulated in nanogels versus standard 0.1% fluocinolone acetonide oral paste in patients with atrophic-erosive oral lichen planus. Thirty eligible participants will be randomly assigned to one of the two topical treatment arms and treated for four weeks. Outcomes include changes in the Oral Lichen Planus Disease Activity Scale (OLP-DAS) and patient satisfaction measures, with monitoring for side effects. The trial is conducted at the Faculty of Dentistry, Chulalongkorn University, and aims to determine whether improved curcumin delivery offers similar efficacy with better tolerability than corticosteroids.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Ability to provide written informed consent
* Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP)
* Presence of symptoms (NRS pain score \> 0 at baseline)
* Ability to communicate and follow instructions
* Willingness to apply oral paste treatment and comply with study protocol

Exclusion Criteria:

* Pregnancy or lactation
* Current orthodontic treatment
* Uncontrolled diabetes mellitus (HbA1c \> 7% or FPG \> 130 mg/dL)
* Use of anticoagulants or antiplatelet agents
* Severe dry mouth (Challacombe score \> 7)
* History of gastric ulcers, duodenal ulcers, or gallstones
* Presence of any active malignancy or infection
* Use of topical/systemic treatment for OLP in the past 2 weeks
* Current use of immunosuppressants
* Known allergy to corticosteroids or herbal agents such as turmeric
* Diagnosis of oral lichenoid contact lesion or graft-versus-host disease (GVHD)
* History of allogeneic bone marrow transplantation
* Current smokers

Where it's running

• Faculty of Dentistry, Chulalongkorn University
  Bangkok, Thailand Recruiting

Study contacts

• Principal investigator: Pirawish Limlawan, D.D.S., Ph.D. — Faculty of Dentistry, Chulalongkorn University
• Study coordinator: Tossapol Maneethorn, D.D.S.
• Email: comeblack_ubama@hotmail.com
• Phone: 086-9253975

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Salivary IL-8 and Serum IL-6 as Biomarkers to Distinguish Oral Premalignant Disorders in Smokers and Never-Smokers

  This study tests whether salivary IL-8 and blood IL-6 can help tell apart adults with oral premalignant conditions from those with healthy mouths, and whether smoking influences these markers.

  Recruiting British University In Egypt · Cairo · NCT07915570

• OROSEDAL use in sore throat and minor oral lesions

  This is a real-world, non-interventional study checking how well OROSEDAL works and how safe it is in people aged 8 and older who have sore throats or small mouth lesions in routine clinical practice.

  Recruiting Laboratoires Elerte · Multiple Locations · NCT07620353

• Light-based therapies versus clobetasol gel for erosive oral lichen planus

  This trial will test whether two light-based treatments (photobiomodulation or photodynamic therapy) or standard topical clobetasol better heal erosive oral lichen planus, reduce pain, and prevent recurrence in adults.

  Recruiting Medical University of Silesia · Zabrze, Silesian Voivodeship · NCT07278999

• Adding oral tofacitinib to topical steroid ointment for moderate-to-severe oral lichen planus

  This study will test whether taking oral tofacitinib along with standard topical triamcinolone helps adults with moderate-to-severe oral lichen planus get better than steroid ointment alone.

  Recruiting Phase 4 All India Institute of Medical Sciences, Bhubaneswar · Bhubaneswar, Odisha · NCT07131813

• Mucoadhesive patch treatment for symptomatic oral lichen planus

  This trial will test whether a mucoadhesive patch with clobetasol, with or without resveratrol, reduces pain and improves symptoms in adults with oral lichen planus.

  Recruiting Phase 2 University of Palermo · Palermo, Italy · NCT07100613

• Topical bromelain versus topical corticosteroid for oral lichen planus

  This trial will test whether a pineapple-derived enzyme gel (bromelain), alone or combined with a topical steroid, helps people with symptomatic oral lichen planus heal and have less pain.

  Recruiting Phase 2 Cairo University · Cairo, Cairo Governorate · NCT06981767

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.