Culturally adapted intervention for self-harm in individuals with substance use disorder in Pakistan
Culturally Adapted Manually Assisted Problem-Solving Intervention (CMAP) Plus CBT Based Motivational Interviewing for Self-Harm in Individuals with Substance Use Disorder in Pakistan: a Feasibility RCT
This study is testing a new therapy called CMAP Plus to see if it helps people in Pakistan with substance use disorder who self-harm, compared to those who only get standard treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Pakistan Institute of Living and Learning Academic / other |
| Locations | 1 site (Lahore) |
| Trial ID | NCT05476601 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the feasibility and acceptability of a culturally adapted cognitive-behavioral intervention called CMAP Plus for individuals with substance use disorder (SUD) who engage in self-harm. It will involve a mixed-method feasibility randomized controlled trial conducted across six major cities in Pakistan, recruiting 80 participants from hospitals and addiction rehabilitation centers. Participants will be randomly assigned to receive either the CMAP Plus intervention alongside standard treatment or standard treatment alone, with the intervention consisting of 12 weekly sessions delivered by trained therapists. The study will also explore participants' experiences with the intervention.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18 and above, diagnosed with substance use disorder, and who have experienced self-harm in the last three months.
Not a fit: Patients with other mental disorders such as schizophrenia, bipolar disorder, or personality disorders may not benefit from this intervention.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce self-harm behaviors in individuals with substance use disorder.
How similar studies have performed: While this approach is culturally adapted, similar interventions have shown promise in other contexts, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 and above. * Individuals diagnosed with SUD on DSM-5 criteria of mental disorders. * Having episodes of self-harm in last three months defined as a deliberate act to harm one's own body including but not limited to self-cutting, self-biting, self-poisoning, self-scratching, self-burning, self-hitting, pulling hair etc. assessed by deliberate self-harm inventory. * Capable to give informed consent. * Those who have completed detoxification process. Exclusion Criteria: * Participants with DSM-5 criteria of mental disorder other than SUD; due to a general medical condition or dementia, delirium, schizophrenia, bipolar disorder, personality disorders, learning disability or any other condition to the extent that engagement in the intervention would not be possible, e.g. communication difficulties. * Unlikely to be available for outcome assessments (temporary residence).
Where this trial is running
Lahore
- Pakistan Recovery Oasis — Lahore, Pakistan (Recruiting)
Study contacts
- Principal investigator: Nusrat Husain — University of Manchester
- Study coordinator: Muqaddas Asif
- Email: muqaddasasif@pill.org.pk
- Phone: 03364057787
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.