Cryotherapy treatment for chronic cough
Single-center Clinical Study on the Safety and Effect of Bronchoscopic Cryotherapy in Patients With Chronic Cough
This study is testing a cryotherapy treatment to see if it can help people with a chronic cough that lasts more than 8 weeks feel better and improve their quality of life.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Guangzhou Medical University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06378671 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the safety and effectiveness of a cryotherapy treatment system for patients suffering from chronic cough. It will involve a prospective, randomized, controlled design with 20 participants, focusing on individuals with cough of unknown cause lasting more than 8 weeks. The study will assess the impact of cryotherapy on cough frequency and severity, as well as overall quality of life, using various evaluation criteria. The trial is sponsored by Guangzhou Medical University in collaboration with Ningbo SensCure Biotechnology Co., Ltd.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 with chronic cough of unknown etiology lasting over 8 weeks.
Not a fit: Patients with severe underlying conditions or those unable to tolerate bronchoscopy procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce chronic cough symptoms and improve patients' quality of life.
How similar studies have performed: While cryotherapy has shown efficacy in other airway diseases, this specific application for chronic cough is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria(To be eligible, all of the following criteria must be met): * Age between 18 and 65 years, regardless of gender; * Patients with cough of unknown etiology or cause, lasting for more than 8 weeks; * Cough Visual Analogue Scale (VAS) score ≥ 50； * Willingness to provide voluntary informed consent and agree to follow-up; * The investigator believes that the overall status of the subjects does not affect the evaluation and completion of the trial. Exclusion Criteria(Any one of the following criteria must not be met to be eligible): * Presence of other diseases that may affect treatment efficacy and prognosis. * Severe underlying conditions such as heart, brain, or lung diseases. * Inability to tolerate bronchoscopy procedures and painless anesthesia. * Women who are pregnant, breastfeeding, or planning pregnancy. * Intravenous drug users. * Participation in or currently participating in other clinical studies involving drugs, devices, or other interventions within the month prior to enrollment. * Other conditions deemed unsuitable for inclusion in this study by the investigators, such as anatomical unsuitability, psychiatric disorders, or psychological disorders.
Where this trial is running
Guangzhou, Guangdong
- The First Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Study coordinator: Shiyue Li
- Email: lishiyue@gird.cn
- Phone: +86 13902233925
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.