Cryopreservation of ovarian tissue and its effects on ovarian function
Official title: Cryopreservation Of Ovarian Tissue: Assessment Of Reimplantation Rate And Effects On Ovarian Function
Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06835088 · Data updated 2026-11-12
This study tests if freezing and later reimplanting ovarian tissue can help women with premature ovarian failure, often caused by cancer treatments, regain their ovarian function.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 13 Years to 55 Years |
| Sex | Women only |
| Enrollment | 400 (estimated) |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Bologna) |
| Status | Recruiting |
| Started | September 12, 2021 |
| Main results expected | December 31, 2030 |
| Study ends | December 30, 2031 |
| Registry record updated | February 19, 2025 |
| Trial ID | NCT06835088 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 13-55 who require gonadotropic treatments and have undergone ovarian tissue cryopreservation.
✕Probably not a fit
Patients with active oncological pathology or relapse may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on the cryopreservation of ovarian tissue in patients facing premature ovarian failure (POI) due to gonadotoxic treatments like chemotherapy and radiotherapy. It aims to evaluate the reimplantation rate of the cryopreserved ovarian tissue and its subsequent effects on ovarian function. The study includes patients aged 13-55 who have undergone ovarian tissue sampling and cryopreservation at a specific medical facility. The findings could provide insights into the effectiveness of this fertility preservation method for cancer patients.
Why it matters
Potential benefit: If successful, this study could enhance fertility preservation options for cancer patients facing premature ovarian failure.
How similar studies have gone: While the approach of ovarian tissue cryopreservation has been explored, this specific observational study aims to provide further insights into its effectiveness, making it a valuable addition to existing literature.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 13-55 years * Suffering from diseases that require gonadotropic treatments * Have been subjected to sampling and cryopreservation of ovarian tissue at the Operative Unit of Gynecology and Pathophysiology of Human Reproduction of the Sant'Orsola Polyclinic in Bologna * Informed Consent Acquisition Exclusion Criteria: \- Oncological pathology still active or relapse
Where it's running
-
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy Recruiting
Study contacts
- Principal investigator: Renato Seracchioli, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Renato Seracchioli, MD
- Email: renato.seracchioli@aosp.bo.it
- Phone: +390512143944
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.