CRPS rehabilitation with graded imagery and desensitization tailored to you

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will deliver an individualized rehabilitation program for CRPS that combines graded motor imagery and tactile desensitization within a psychologically informed care framework. The study uses a randomized multiple-baseline single-case design to track how each participant responds before and after starting treatment. Outcomes include daily CRPS interference, pain levels, and limb function, measured repeatedly, with additional assessments at baseline and 12 months. For a subset, MRI will compare brain structure with healthy controls and monitor changes over time. Two work packages jointly address clinical effects and neuroimaging under real-world clinical conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older. For participants included in WP2 (MRI), the maximum age is 70 years.
* Diagnosis of Complex Regional Pain Syndrome (CRPS) according to the Budapest criteria.
* CRPS affecting a single upper or lower limb.
* Triggering trauma or onset of pain more than 3 months before inclusion.

Exclusion Criteria:

* Drug abuse.
* Malignant or progressive disease, systemic disease, or neurodegenerative disease.
* Other severe pain conditions.
* Severe anxiety or depression.
* Disabling fatigue or myalgic encephalomyelitis (ME).
* Use of opioid medication exceeding 100 mg oral morphine equivalents (OMEQ).

Additional Exclusion Criteria for WP2 (MRI):

* History of seizures.
* Neurological or neurosurgical disorders.
* Significant cardiac or systemic illness.
* Implanted metallic or electronic devices incompatible with MRI.
* Diagnosis of a developmental disorder.
* Current use of antipsychotic medications, benzodiazepines, or other pharmacological agents that may influence MRI measurements.
* Pregnancy or lactation.
* Phobia of MRI examination.

Where it's running

• University Hospital of North Norway
  Tromsø, Norway Recruiting

Study contacts

• Study coordinator: Lena Danielsson, PhD
• Email: lena.danielsson@unn.no

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-invasive brain stimulation to see if it changes pain avoidance in CRPS

  This study tests whether a gentle brain stimulation method called tACS can change how people with complex regional pain syndrome avoid activities that might worsen their pain.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07791966

• tDCS for CRPS: see if a non‑invasive brain stimulation helps reduce pain

  This trial tests whether transcranial direct current stimulation can lessen pain and improve mood and function for people with complex regional pain syndrome.

  Recruiting Polyclinique de l'Europe · Saint-Nazaire · NCT07361692

• Peripersonal space changes with upper limb segmental exclusion

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  Recruiting Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est · Nancy · NCT07349173

• What happens after neridronate treatment for CRPS Type 1

  This registry follows people with CRPS Type 1 to see how long the benefits of IV neridronate last over 12 to 24 months.

  Recruiting Ambros Therapeutics, Inc. · Durham, North Carolina · NCT07811362

• CRPS of the hand: Contrast plus compression vs whirlpool therapy

  This randomized study tests whether a combined contrast therapy with intermittent compression helps people with CRPS-I in the hand and wrist more than whirlpool therapy.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle · NCT07744269

• Perineural incobotulinumtoxin-A for unilateral CRPS of an arm or leg

  This study will try a single ultrasound-guided perineural injection of incobotulinumtoxin-A to see if it is safe and tolerable for adults with long-standing unilateral CRPS of an arm or leg.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Glostrup, Region Sjælland · NCT07473635

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.